Sökning: onr:"swepub:oai:DiVA.org:kth-185064" > Dynamics inside the...
Fältnamn | Indikatorer | Metadata |
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000 | 03606naa a2200493 4500 | |
001 | oai:DiVA.org:kth-185064 | |
003 | SwePub | |
008 | 160411s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133183878 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1850642 URI |
024 | 7 | a https://doi.org/10.1073/pnas.15192101132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1331838782 URI |
040 | a (SwePub)kthd (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Li, Qinu Karolinska Institutet4 aut |
245 | 1 0 | a Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape |
264 | c 2016-02-29 | |
264 | 1 | b National Academy of Sciences,c 2016 |
338 | a print2 rdacarrier | |
500 | a QC 20160415 | |
520 | a The observed intercellular heterogeneity within a clonal cell population can be mapped as dynamical states clustered around an attractor point in gene expression space, owing to a balance between homeostatic forces and stochastic fluctuations. These dynamics have led to the cancer cell attractor conceptual model, with implications for both carcinogenesis and new therapeutic concepts. Immortalized and malignant EBV-carrying B-cell lines were used to explore this model and characterize the detailed structure of cell attractors. Any subpopulation selected from a population of cells repopulated the whole original basin of attraction within days to weeks. Cells at the basin edges were unstable and prone to apoptosis. Cells continuously changed states within their own attractor, thus driving the repopulation, as shown by fluorescent dye tracing. Perturbations of key regulatory genes induced a jump to a nearby attractor. Using the Fokker-Planck equation, this cell population behavior could be described as two virtual, opposing influences on the cells: one attracting toward the center and the other promoting diffusion in state space (noise). Transcriptome analysis suggests that these forces result from high-dimensional dynamics of the gene regulatory network. We propose that they can be generalized to all cancer cell populations and represent intrinsic behaviors of tumors, offering a previously unidentified characteristic for studying cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a cancer cell attractor | |
653 | a cell heterogeneity | |
653 | a edge cells | |
653 | a gene regulatory network | |
653 | a cell population dynamics | |
700 | 1 | a Wennborg, Andersu Karolinska Institutet4 aut |
700 | 1 | a Aurell, Eriku KTH,Albanova4 aut0 (Swepub:kth)u1uc9cqo |
700 | 1 | a Dekel, Erez4 aut |
700 | 1 | a Zou, Jie-Zhi4 aut |
700 | 1 | a Xu, Yuting4 aut |
700 | 1 | a Huang, Sui4 aut |
700 | 1 | a Ernberg, Ingemaru Karolinska Institutet4 aut |
710 | 2 | a KTHb Karolinska Institutet4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : National Academy of Sciencesg 113:10, s. 2672-2677q 113:10<2672-2677x 0027-8424x 1091-6490 |
856 | 4 | u https://www.pnas.org/content/pnas/113/10/2672.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185064 |
856 | 4 8 | u https://doi.org/10.1073/pnas.1519210113 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133183878 |
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