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Exercise during Sho...
Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing
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Tellez, Helio Fernandez (author)
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Morrison, Shawnda A. (author)
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Neyt, Xavier (author)
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Mairesse, Olivier (author)
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Piacentini, Maria Francesca (author)
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Macdonald-Nethercott, Eoin (author)
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Pangerc, Andrej (author)
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Dolenc-Groselj, Leja (author)
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- Eiken, Ola (author)
- KTH,Omgivningsfysiologi
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Pattyn, Nathalie (author)
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Mekjavic, Igor B. (author)
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Meeusen, Romain (author)
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(creator_code:org_t)
- Associated Professional Sleep Societies, 2016
- 2016
- English.
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In: Sleep. - : Associated Professional Sleep Societies. - 0161-8105 .- 1550-9109. ; 39:4, s. 773-783
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
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- Study Objectives: Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia. Methods: Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 +/- 3 y, height: 1.79 +/- 0.06 m, mass: 74 +/- 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 +/- 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 +/- 9 y, height: 1.77 +/- 0.09 m, mass: 75 +/- 10 kg) lived for 12-14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables. Results: Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 +/- 51, EX: 91 +/- 59; Night10 = CON: 32 +/- 32, EX: 92 +/- 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R-2 = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO(2); R-2 = 0.3062; P = 0.049). Conclusions: Data indicate that exercise (physical activity) per se affects night SpO(2) concentrations and AHI after a minimum of two bouts of moderateintensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Antarctica
- sleep apnea
- confinement
- cycling
- high altitude
- oxygen saturation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Tellez, Helio Fe ...
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Morrison, Shawnd ...
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Neyt, Xavier
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Mairesse, Olivie ...
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Piacentini, Mari ...
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Macdonald-Nether ...
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show more...
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Pangerc, Andrej
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Dolenc-Groselj, ...
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Eiken, Ola
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Pattyn, Nathalie
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Mekjavic, Igor B ...
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Meeusen, Romain
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Sleep
- By the university
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Royal Institute of Technology