Sökning: onr:"swepub:oai:DiVA.org:kth-198742" >
A simple polyol-fre...
A simple polyol-free synthesis route to Gd 2O 3 nanoparticles for MRI applications : An experimental and theoretical study
-
- Ahrén, Maria (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
-
- Selegård, Linnéa (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
-
- Söderlind, Fredrik (författare)
- Linköpings universitet,Nanostrukturerade material,Tekniska högskolan
-
visa fler...
-
- Linares, Mathieu (författare)
- Linköpings universitet,Beräkningsfysik,Tekniska högskolan
-
- Kauczor, Joanna (författare)
- Linköpings universitet,Beräkningsfysik,Tekniska högskolan
-
- Norman, Patrick (författare)
- Linköpings universitet,Beräkningsfysik,Tekniska högskolan
-
- Käll, Per-Olov (författare)
- Linköpings universitet,Fysikalisk Kemi,Tekniska högskolan
-
- Uvdal, Kajsa (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
-
visa färre...
-
(creator_code:org_t)
- 2012-07-10
- 2012
- Engelska.
-
Ingår i: Journal of nanoparticle research. - : Springer. - 1388-0764 .- 1572-896X. ; 14:8
- Relaterad länk:
-
http://liu.diva-port...
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Chelated gadolinium ions, e.g., Gd-DTPA, are today used clinically as contrast agents for magnetic resonance imaging (MRI). An attractive alternative contrast agent is composed of gadolinium oxide nanoparticles as they have shown to provide enhanced contrast and, in principle, more straightforward molecular capping possibilities. In this study, we report a new, simple, and polyol-free way of synthesizing 4-5-nm-sized Gd 2O 3 nanoparticles at room temperature, with high stability and water solubility. The nanoparticles induce high-proton relaxivity compared to Gd-DTPA showing r 1 and r 2 values almost as high as those for free Gd 3+ ions in water. The Gd 2O 3 nanoparticles are capped with acetate and carbonate groups, as shown with infrared spectroscopy, near-edge X-ray absorption spectroscopy, X-ray photoelectron spectroscopy and combined thermogravimetric and mass spectroscopy analysis. Interpretation of infrared spectroscopy data is corroborated by extensive quantum chemical calculations. This nanomaterial is easily prepared and has promising properties to function as a core in a future contrast agent for MRI.
Ämnesord
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
Nyckelord
- Gadolinium oxide
- IR
- Relaxivity
- Synthesis
- Toxicity
- XPS
- Carbonate group
- Contrast agent
- Enhanced contrast
- Gadolinium ions
- Gd-DTPA
- High stability
- Mass spectroscopy
- Nanomaterial
- Near-edge x-ray absorption
- Quantum chemical calculations
- Room temperature
- Synthesis route
- Theoretical study
- Thermogravimetric
- Water solubilities
- X-ray photoelectrons
- Alcohols
- Infrared spectroscopy
- Iridium
- Magnetic resonance imaging
- Mass spectrometry
- Nanoparticles
- Photoelectrons
- Quantum chemistry
- Synthesis (chemical)
- Thermogravimetric analysis
- X ray absorption spectroscopy
- X ray photoelectron spectroscopy
- Gadolinium
- gadolinium chloride
- gadolinium oxide nanoparticle
- gadolinium pentetate
- nanoparticle
- nuclear magnetic resonance imaging agent
- polyol
- unclassified drug
- article
- chemical composition
- drug synthesis
- light scattering
- molecular stability
- nuclear magnetic resonance imaging
- particle size
- priority journal
- thermogravimetry
- transmission electron microscopy
- X ray diffraction
- TECHNOLOGY
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas