Search: onr:"swepub:oai:DiVA.org:kth-207983" >
Elevated levels of ...
Elevated levels of adipokines predict outcome after acute myocardial infarction : A long-term follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort
-
- Ritsinger, V. (author)
- Karolinska Institutet
-
- Brismar, K. (author)
- Karolinska Institutet
-
Malmberg, K. (author)
-
show more...
-
- Mellbin, L. (author)
- Karolinska Institutet
-
- Näsman, Per, 1954- (author)
- KTH,Transportplanering, ekonomi och teknik,Centre for Safety Research
-
- Rydén, L. (author)
- Karolinska Institutet
-
- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
-
Tenerz, Å. (author)
-
- Norhammar, A. (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2016-12-21
- 2017
- English.
-
In: Diabetes & Vascular Disease Research. - : Sage Publications. - 1479-1641 .- 1752-8984. ; 14:2, s. 77-87
- Related links:
-
https://journals.sag...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objective: Adiponectin and leptin are associated with insulin resistance and cardiovascular disease. Information on the prognostic value after an acute myocardial infarction is still conflicting. Methods: Patients (n = 180) without known diabetes and with admission glucose of <11 mmol/L admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/heart failure) until the end of 2011 (median: 11.6 years). Plasma adiponectin and leptin were related to outcome in Cox proportional-hazard regression analyses. Results: Median age was 64 years and 69% were male. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event. Adiponectin at discharge predicted cardiovascular events (hazard ratio; 95% confidence interval; 1.45; 1.02-2.07, p = 0.038), total mortality (2.53; 1.64-3.91, p < 0.001) and cancer mortality (3.64; 1.51-8.74, p = 0.004). After adjustment for age, sex, body mass index, previous myocardial infarction and heart failure, adiponectin predicted total mortality (1.79; 1.07-3.00, p = 0.027) but not cardiovascular events. High levels of leptin were associated with cardiovascular events during the first 7 years, after which the association was attenuated. Leptin did not predict total mortality. Conclusion: In patients with acute myocardial infarction but without previously known diabetes, high levels of adiponectin at discharge predicted total mortality. The present results support the hypothesis that high rather than low levels of adiponectin predict mortality after acute myocardial infarction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute myocardial infarction
- adipokines
- diabetes
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ritsinger, V.
-
Brismar, K.
-
Malmberg, K.
-
Mellbin, L.
-
Näsman, Per, 195 ...
-
Rydén, L.
-
show more...
-
Söderberg, Stefa ...
-
Tenerz, Å.
-
Norhammar, A.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Diabetes & Vascu ...
- By the university
-
Royal Institute of Technology
-
Umeå University
-
Karolinska Institutet