Search: onr:"swepub:oai:DiVA.org:kth-22304" >
Subcellular interac...
Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
-
- Hellgren Kotaleski, Jeanette (author)
- KTH,Numerisk analys och datalogi, NADA
-
Lester, D. (author)
-
Blackwell, K. T. (author)
-
(creator_code:org_t)
- 2002
- 2002
- English.
-
In: Integrative Physiological & Behavioral Science. - 1053-881X .- 2168-7846. ; 37:4, s. 265-292
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA(2)). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.
Keyword
- classical conditioning
- Purkinje cell
- protein kinase C
- IP3 induced calcium release
- computer modeling
- LTD
- long-term depression
- inositol 1,4,5-trisphosphate
- calcium
- membrane
- range
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database