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Transcriptome profi...
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia
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- Danielsson, Frida (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Fasterius, Erik (författare)
- KTH,Proteomik
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- Sullivan, Devin (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Hases, Linnea (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Huddinge, Sweden
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- Sanli, Kemal (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Zhang, Cheng (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Al-Khalili Szigyarto, Cristina (författare)
- KTH,Proteomik
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Huss, M. (författare)
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- Uhlén, Mathias (författare)
- KTH,Proteomik,Science for Life Laboratory, SciLifeLab,Technical University of Denmark, Hørsholm, Denmark
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- Williams, Cecilia, 1969- (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Huddinge, Sweden
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- Lundberg, Emma (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2018-04-13
- 2018
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals LLC. - 1949-2553. ; 9:28, s. 19730-19744
- Relaterad länk:
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https://doi.org/10.1...
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https://kth.diva-por... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In tumor tissues, hypoxia is a commonly observed feature resulting from rapidly proliferating cancer cells outgrowing their surrounding vasculature network. Transformed cancer cells are known to exhibit phenotypic alterations, enabling continuous proliferation despite a limited oxygen supply. The four-step isogenic BJ cell model enables studies of defined steps of tumorigenesis: the normal, immortalized, transformed, and metastasizing stages. By transcriptome profiling under atmospheric and moderate hypoxic (3% O2) conditions, we observed that despite being highly similar, the four cell lines of the BJ model responded strikingly different to hypoxia. Besides corroborating many of the known responses to hypoxia, we demonstrate that the transcriptome adaptation to moderate hypoxia resembles the process of malignant transformation. The transformed cells displayed a distinct capability of metabolic switching, reflected in reversed gene expression patterns for several genes involved in oxidative phosphorylation and glycolytic pathways. By profiling the stage-specific responses to hypoxia, we identified ASS1 as a potential prognostic marker in hypoxic tumors. This study demonstrates the usefulness of the BJ cell model for highlighting the interconnection of pathways involved in malignant transformation and hypoxic response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Hypoxia
- Malignant transformation
- Transcriptomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Danielsson, Frid ...
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Fasterius, Erik
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Sullivan, Devin
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Hases, Linnea
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Sanli, Kemal
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Zhang, Cheng
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visa fler...
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Mardinoglu, Adil
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Al-Khalili Szigy ...
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Huss, M.
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Uhlén, Mathias
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Williams, Cecili ...
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Lundberg, Emma
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Oncotarget
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet