Silver-Catalyzed [3+1+1] Annulation of Nitrones with Isocyanoacetates as an Approach to 1,4,5-Trisubstituted Imidazoles

• A silver-catalyzed protocol for [3+1+1] annulation of nitrones and isocyanoacetates is reported. The reaction is proposed to proceed through sequential [3+2] cycloaddition, ring-opening, cyclization-oxidation, and dealkylation, allowing access to a broad scope of valuable polysubstituted imidazoles in high yields.

Subject headings

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Keyword

Annulations

Cascade reactions

Imidazoles

Isocyanides

Silver

Publication and Content Type

ref (subject category)

art (subject category)