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Persisting Salivary...
Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19 : A Complementary Approach to Population Surveys
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- Alkharaan, Hassan (author)
- Karolinska Inst, Dept Dent Med, Alfred Nobels Alle 8, S-14104 Stockholm, Sweden.
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- Bayati, Shaghayegh (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Hellström, Cecilia (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Aleman, Soo (author)
- Karolinska Institutet
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- Olsson, Annika (author)
- Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
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- Lindahl, Karin (author)
- Karolinska Institutet
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- Bogdanovic, Gordana (author)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
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- Healy, Katie (author)
- Karolinska Inst, Dept Dent Med, Alfred Nobels Alle 8, S-14104 Stockholm, Sweden.
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- Tsilingaridis, Georgios (author)
- Karolinska Institutet
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- De Palma, Patricia (author)
- Karolinska Institutet
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- Hober, Sophia, Professor, 1965- (author)
- KTH,Proteinteknologi
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- Månberg, Anna, 1985- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Pin, Elisa (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Chen, Margaret Sallberg (author)
- Karolinska Institutet
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Karolinska Inst, Dept Dent Med, Alfred Nobels Alle 8, S-14104 Stockholm, Sweden Affinitets-proteomik (creator_code:org_t)
- 2021-05-12
- 2021
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 224:3, s. 407-414
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background. Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking. Methods. Using a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3). Results. Salivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments. Conclusions. Unlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- antibody
- convalescence
- COVID-19
- immunoassay
- saliva
- serology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alkharaan, Hassa ...
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Bayati, Shaghaye ...
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Hellström, Cecil ...
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Aleman, Soo
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Olsson, Annika
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Lindahl, Karin
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Bogdanovic, Gord ...
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Healy, Katie
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Tsilingaridis, G ...
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De Palma, Patric ...
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Hober, Sophia, P ...
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Månberg, Anna, 1 ...
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Nilsson, Peter
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Pin, Elisa
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Chen, Margaret S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet