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Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
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- Högelin, Klara Asplund (author)
- Karolinska Institutet
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- Ruffin, Nicolas (author)
- Karolinska Institutet
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- Pin, Elisa (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- (creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
- In: iScience. - : Elsevier BV. - 2589-0042. ; 24:9
- Journal article (peer-reviewed)
Abstract
Subject headings
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- B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-gamma and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- Grönlund, Hans
- Nilsson, Peter
- Khademi, Mohsen
- Olsson, Tomas
- Piehl, Fredrik
- Al Nimer, Faiez
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- Royal Institute of Technology
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