Search: onr:"swepub:oai:DiVA.org:kth-303538" >
Development of humo...
-
Högelin, Klara AsplundKarolinska Institutet
(author)
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
Elsevier BV,2021
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:kth-303538
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-303538URI
-
https://doi.org/10.1016/j.isci.2021.103078DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:147751254URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
QC 20211103
-
B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-gamma and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ruffin, NicolasKarolinska Institutet
(author)
-
Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1pmjyje
(author)
-
Månberg, Anna,1985-KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1g5roxd
(author)
-
Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi(Swepub:kth)u11qqzc1
(author)
-
Gafvelin, GuroKarolinska Inst, Ctr Mol Med L8 02, Dept Clin Neurosci, Therapeut Immune Design Unit, S-17176 Stockholm, Sweden.
(author)
-
Grönlund, HansKarolinska Institutet
(author)
-
Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1ws88sk
(author)
-
Khademi, MohsenKarolinska Institutet
(author)
-
Olsson, TomasKarolinska Institutet
(author)
-
Piehl, FredrikKarolinska Institutet
(author)
-
Al Nimer, FaiezKarolinska Institutet
(author)
-
Karolinska InstitutetAffinitets-proteomik
(creator_code:org_t)
Related titles
-
In:iScience: Elsevier BV24:92589-0042
Internet link
Find in a library
-
iScience
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Högelin, Klara A ...
-
Ruffin, Nicolas
-
Pin, Elisa
-
Månberg, Anna, 1 ...
-
Hober, Sophia, P ...
-
Gafvelin, Guro
-
show more...
-
Grönlund, Hans
-
Nilsson, Peter
-
Khademi, Mohsen
-
Olsson, Tomas
-
Piehl, Fredrik
-
Al Nimer, Faiez
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
iScience
- By the university
-
Royal Institute of Technology
-
Karolinska Institutet