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Search: onr:"swepub:oai:DiVA.org:kth-304598" > The spatial landsca...

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The spatial landscape of clonal somatic mutations in benign and malignant tissue

Erickson, Andrew (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK.
Berglund, Emelie (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
He, Mengxiao (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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Marklund, Maja (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Mirzazadeh, Reza (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Schultz, Niklas (author)
Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
Bergenstrahle, Ludvig (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Kvastad, Linda (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Andersson, Alma (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Bergenstråhle, Joseph (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Larsson, Ludvig (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Shamikh, Alia (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Basmaci, Elisa (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Diaz De Ståhl, Teresita (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Rajakumar, Timothy (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK.
Thrane, Kim (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Ji, Andrew L (author)
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Khavari, Paul A (author)
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Tarish, Firaz (author)
Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
Tanoglidi, Anna (author)
Department of Clinical Pathology, University Uppsala Hospital, Uppsala, Sweden.
Maaskola, Jonas (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Colling, Richard (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK. Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, UK.
Mirtti, Tuomas (author)
Department of Pathology, University of Helsinki & Helsinki University Hospital, Finland. Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Finland. iCAN-Digital Precision Cancer Medicine Flagship, Helsinki, Finland.
Hamdy, Freddie C (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK. Department of Urology, Oxford University Hospitals NHS Foundation Trust, UK.
Woodcock, Dan J (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK. Big Data Institute, Old Road Campus, University of Oxford, UK.
Helleday, Thomas (author)
Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, UK.
Mills, Ian G (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK.
Lamb, Alastair D (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK. Department of Urology, Oxford University Hospitals NHS Foundation Trust, UK.
Lundeberg, Joakim (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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Nuffield Department of Surgical Sciences, University of Oxford, UK Genteknologi (creator_code:org_t)
English.
Related links:
https://urn.kb.se/re...
  • Other publication (other academic/artistic)
Abstract Subject headings
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  • Defining the transition from benign to malignant tissue is fundamental to improve early diagnosis of cancer. Here, we provide an unsupervised approach to study spatial genome integrity in situ to gain molecular insight into clonal relationships. We employed spatially resolved transcriptomics to infer spatial copy number variations in >120 000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of an unsupervised approach to capture the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.

Keyword

Biotechnology
Bioteknologi

Publication and Content Type

vet (subject category)
ovr (subject category)

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