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The spatial landscape of transcriptomes and genomes in pediatric brain tumors

Kvastad, Linda (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Mirzazadeh, Reza (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Larsson, Ludvig (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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Mollbrink, Annelie (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Shamikh, Alia (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Basmaci, Elisa (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Prochazka, Gabriela (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Diaz De Ståhl, Teresita (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Erickson, Andrew (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK.
Lamb, Alastair D (author)
Nuffield Department of Surgical Sciences, University of Oxford, UK. Department of Urology, Oxford University Hospitals NHS Foundation Trust, UK.
Nistér, Monica (author)
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Lundeberg, Joakim (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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 (creator_code:org_t)
English.
Related links:
https://urn.kb.se/re...
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  • Treatment of pediatric brain tumors is continually being improved; still, there is a great need for new treatment options. Here we explore the spatial transcriptomic and genomic landscape in a cohort of pediatric brain tumors using a new generation of unbiased methodologies. We demonstrate the gene expression patterns of the essential cancer-related gene programs of epithelial-to-mesenchymal transition (EMT), the reverse process mesenchymal-to-epithelial transition (MET), and tumor microenvironment (TME) observations through microglia. Furthermore, we identify the gene expression of SPP1 by microglia in the TME as a potential prognostic mRNA marker - in pediatric brain tumor relapse patients.

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Bioteknologi
Biotechnology

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