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Structural Insights...
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Moonens, KristofVIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier BV,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-305697
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305697URI
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https://doi.org/10.1016/j.chom.2015.12.004DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117839URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132941926URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20211206
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The Helicobacter pylori adhesin BabA binds mucosal ABO/Le b blood group (bg) carbohydrates. BabA facilitates bacterial attachment to gastric surfaces, increasing strain virulence and forming a recognized risk factor for peptic ulcers and gastric cancer. High sequence variation causes BabA functional diversity, but the underlying structural-molecular determinants are unknown. We generated X-ray structures of representative BabA isoforms that reveal a polymorphic, three-pronged Le(b) binding site. Two diversity loops, DL1 and DL2, provide adaptive control to binding affinity, notably ABO versus O bg preference. H. pylori strains can switch bg preference with single DL1 amino acid substitutions, and can coexpress functionally divergent BabA isoforms. The anchor point for receptor binding is the embrace of an ABO fucose residue by a disulfide-clasped loop, which is inactivated by reduction. Treatment with the redox-active pharmaceutic N-acetylcysteine lowers gastric mucosal neutrophil infiltration in H. pylori-infected Le(b)-expressing mice, providing perspectives on possible H. pylori eradication therapies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Gideonsson, PärUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)parjon03
(author)
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Subedi, SureshVIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Bugaytsova, JeannaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)zhbu0001
(author)
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Romao, EmaVrije Univ Brussel, Cellular & Mol Immunol, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Mendez, MelissaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)mema0008
(author)
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Nordén, JennyUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)jeynon99
(author)
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Fallah, MahsaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)mafa0138
(author)
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Rakhimova, LenaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)olra0003
(author)
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Shevtsova, AnnaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)ansh0012
(author)
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Lahmann, MartinaBangor Univ, Sch Chem, Deiniol Rd, Bangor LL57 2UW, Gwynedd, Wales.(Swepub:kth)u190mcjj
(author)
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Castaldo, GaetanoVIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Brännström, KristofferUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)krbr0001
(author)
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Coppens, FannyVIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Lo, Alvin W.VIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Ny, TorUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)tony0001
(author)
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Solnick, Jay V.Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA.;Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA.;Univ Calif Davis, Sch Med, Dept Med, Sacramento, CA 95817 USA.;Univ Calif Davis, Sch Med, Dept Microbiol & Immunol, Sacramento, CA 95817 USA.
(author)
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Vandenbussche, GuyUniv Libre Bruxelles, Struct & Funct Biol Membranes, B-1050 Brussels, Belgium.
(author)
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Oscarson, StefanUniv Coll Dublin, Sch Chem, Ctr Synth & Chem Biol, Dublin 4, Ireland.
(author)
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Hammarstrom, LennartKarolinska Institutet
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Arnqvist, AnnaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)anar0001
(author)
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Berg, Douglas E.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
(author)
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Muyldermans, SergeVrije Univ Brussel, Cellular & Mol Immunol, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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Borén, ThomasUmeå Univ, Dept Med Biochem & Biophys, SE-90187 Umeå, Sweden.(Swepub:umu)thbo0001
(author)
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Remaut, HanVIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.
(author)
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VIB, Struct Biol Res Ctr, Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.;Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium.Institutionen för medicinsk kemi och biofysik
(creator_code:org_t)
Related titles
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In:Cell Host and Microbe: Elsevier BV19:1, s. 55-661931-31281934-6069
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- By the author/editor
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Moonens, Kristof
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Gideonsson, Pär
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Subedi, Suresh
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Bugaytsova, Jean ...
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Romao, Ema
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Mendez, Melissa
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Nordén, Jenny
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Fallah, Mahsa
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Rakhimova, Lena
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Shevtsova, Anna
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Lahmann, Martina
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Castaldo, Gaetan ...
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Brännström, Kris ...
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Coppens, Fanny
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Lo, Alvin W.
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Ny, Tor
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Solnick, Jay V.
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Vandenbussche, G ...
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Oscarson, Stefan
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Hammarstrom, Len ...
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Arnqvist, Anna
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Berg, Douglas E.
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Muyldermans, Ser ...
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Borén, Thomas
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Remaut, Han
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- MEDICAL AND HEALTH SCIENCES
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Royal Institute of Technology
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