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p Advances and Util...
p Advances and Utility of the Human Plasma Proteome
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- Deutsch, Eric W. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Omenn, Gilbert S. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.;Univ Michigan, Sch Publ Hlth, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ Michigan, Sch Publ Hlth, Dept Internal Med & Human Genet, Ann Arbor, MI 48109 USA.
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- Sun, Zhi (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Maes, Michal (författare)
- Karolinska Institutet
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- Pernemalm, Maria (författare)
- Karolinska Inst, Dept Oncol & Pathol, Sci Life Lab, S-17165 Stockholm, Sweden.
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- Palaniappan, Krishnan K. (författare)
- Freenome, San Francisco, CA 94080 USA.
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- Letunica, Natasha (författare)
- Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
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- Vandenbrouck, Yves (författare)
- Univ Grenoble Alpes, CEA, Inserm U1292, F-38000 Grenoble, France.
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- Brun, Virginie (författare)
- Univ Grenoble Alpes, CEA, Inserm U1292, F-38000 Grenoble, France.
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- Tao, Sheng-ce (författare)
- Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China.
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- Yu, Xiaobo (författare)
- Beijing Inst Life, Natl Ctr Prot Sci, Beijing PHOENIX Ctr, Beijing Proteome Res Ctr,State Key Lab Prote, Beijing 102206, Peoples R China.
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- Geyer, Philipp E. (författare)
- OmicEra Diagnost GmbH, D-82152 Planegg, Germany.
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- Ignjatovic, Vera (författare)
- Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.;Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia.
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- Moritz, Robert L. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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Inst Syst Biol, Seattle, WA 98109 USA Inst Syst Biol, Seattle, WA 98109 USA.;Univ Michigan, Sch Publ Hlth, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ Michigan, Sch Publ Hlth, Dept Internal Med & Human Genet, Ann Arbor, MI 48109 USA. (creator_code:org_t)
- 2021-10-21
- 2021
- Engelska.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 20:12, s. 5241-5263
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- proteomics
- mass spectrometry
- blood
- plasma
- Human Proteome Project
- Human Plasma Proteome Project
- PeptideAtlas
- proximity extension assays (PEA by Olink)
- DNA aptamers (Somascan)
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Deutsch, Eric W.
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Omenn, Gilbert S ...
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Sun, Zhi
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Maes, Michal
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Pernemalm, Maria
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Palaniappan, Kri ...
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visa fler...
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Letunica, Natash ...
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Vandenbrouck, Yv ...
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Brun, Virginie
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Tao, Sheng-ce
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Yu, Xiaobo
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Geyer, Philipp E ...
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Ignjatovic, Vera
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Moritz, Robert L ...
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Schwenk, Jochen ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
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Journal of Prote ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet