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Safety evaluation o...
Safety evaluation of high-risk myocardial micro-biopsy in a swine model
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- Chireh, A. (författare)
- Karolinska Institutet
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- Sandell, Mikael (författare)
- KTH,Mikro- och nanosystemteknik,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; MedTechLabs, Solna, Sweden
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- Grankvist, R. (författare)
- Karolinska Institutet
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Lövljung, V. (författare)
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al-Saadi, J. (författare)
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- Arnberg, F. (författare)
- Karolinska Institutet
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- Lundberg, J. (författare)
- Karolinska Institutet
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- Settergren, M. (författare)
- Karolinska Institutet
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- Holmin, S. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-11-23
- 2022
- Engelska.
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Ingår i: Heart and Vessels. - : Springer Nature. - 0910-8327 .- 1615-2573. ; 37:4, s. 697-704
- Relaterad länk:
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https://doi.org/10.1...
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Endomyocardial biopsy
- Interventional cardiology
- Micro-biopsy
- Safety
- adverse event
- animal
- biopsy
- cardiac muscle
- diagnostic imaging
- heart catheterization
- heart ventricle
- human
- pathology
- pericardial effusion
- pig
- procedures
- Animals
- Cardiac Catheterization
- Heart Ventricles
- Humans
- Myocardium
- Swine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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