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Integrative functio...
Integrative functional analysis uncovers metabolic differences between Candida species
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- Begum, Neelu (författare)
- Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London
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- Lee, Sunjae (författare)
- Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London
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- Pellon, Aize (författare)
- Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London
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- Nasab, Shervin Sadeghi (författare)
- Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London
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- Nielsen, Jens B, 1962 (författare)
- Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Biolnnovat Inst, Ole Maaloes Vej 3, DK-2200 Copenhagen N, Denmark.,Chalmers tekniska högskola,Chalmers University of Technology
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- Uhlén, Mathias (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
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- Moyes, David (författare)
- Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London
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- Shoaie, Saeed (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
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- Portlock, Theo John (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
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Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England King's College London (creator_code:org_t)
- 2022-09-26
- 2022
- Engelska.
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Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 5:1
- Relaterad länk:
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https://doi.org/10.1...
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https://research.cha... (primary) (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Metabolic differences between Candida species are uncovered using the BioFung database alongside genomic and metabolic analysis. Candida species are a dominant constituent of the human mycobiome and associated with the development of several diseases. Understanding the Candida species metabolism could provide key insights into their ability to cause pathogenesis. Here, we have developed the BioFung database, providing an efficient annotation of protein-encoding genes. Along, with BioFung, using carbohydrate-active enzyme (CAZymes) analysis, we have uncovered core and accessory features across Candida species demonstrating plasticity, adaption to the environment and acquired features. We show a greater importance of amino acid metabolism, as functional analysis revealed that all Candida species can employ amino acid metabolism. However, metabolomics revealed that only a specific cluster of species (AGAu species-C. albicans, C. glabrata and C. auris) utilised amino acid metabolism including arginine, cysteine, and methionine metabolism potentially improving their competitive fitness in pathogenesis. We further identified critical metabolic pathways in the AGAu cluster with biomarkers and anti-fungal target potential in the CAZyme profile, polyamine, choline and fatty acid biosynthesis pathways. This study, combining genomic analysis, and validation with gene expression and metabolomics, highlights the metabolic diversity with AGAu species that underlies their remarkable ability to dominate they mycobiome and cause disease.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Begum, Neelu
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Lee, Sunjae
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Pellon, Aize
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Nasab, Shervin S ...
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Nielsen, Jens B, ...
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Uhlén, Mathias
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visa fler...
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Moyes, David
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Shoaie, Saeed
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Portlock, Theo J ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Evolutionsbiolog ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Annan biologi
- Artiklar i publikationen
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Communications B ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Chalmers tekniska högskola