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Computational cardi...
Computational cardiac physiology for new modelers : Origins, foundations, and future
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- Koivumäki, Jussi T. (author)
- Faculty of Medicine and Health Technology, and Centre of Excellence in Body-on-Chip Research, Tampere University, Tampere, Finland
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- Hoffman, Johan, 1974- (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Maleckar, Mary M. (author)
- Computational Physiology Department, Simula Research Laboratory, Oslo, Norway
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- Einevoll, Gaute T. (author)
- Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway; Department of Physics, University of Oslo, Oslo, Norway; Department of Physics, Norwegian University of Life Sciences, Ås, Norway
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- Sundnes, Joakim (author)
- Computational Physiology Department, Simula Research Laboratory, Oslo, Norway
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(creator_code:org_t)
- 2022-08-25
- 2022
- English.
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In: Acta Physiologica. - : Wiley. - 1748-1708 .- 1748-1716. ; 236:2
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mathematical models of the cardiovascular system have come a long way since they were first introduced in the early 19th century. Driven by a rapid development of experimental techniques, numerical methods, and computer hardware, detailed models that describe physical scales from the molecular level up to organs and organ systems have been derived and used for physiological research. Mathematical and computational models can be seen as condensed and quantitative formulations of extensive physiological knowledge and are used for formulating and testing hypotheses, interpreting and directing experimental research, and have contributed substantially to our understanding of cardiovascular physiology. However, in spite of the strengths of mathematics to precisely describe complex relationships and the obvious need for the mathematical and computational models to be informed by experimental data, there still exist considerable barriers between experimental and computational physiological research. In this review, we present a historical overview of the development of mathematical and computational models in cardiovascular physiology, including the current state of the art. We further argue why a tighter integration is needed between experimental and computational scientists in physiology, and point out important obstacles and challenges that must be overcome in order to fully realize the synergy of experimental and computational physiological research.
Subject headings
- NATURVETENSKAP -- Matematik -- Annan matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Other Mathematics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiovascular physiology
- computer models
- mathematical modeling
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