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Protective alleles ...
Protective alleles and precision healthcare in crewed spaceflight
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- Rutter, Lindsay A. (author)
- Univ Tsukuba, Transborder Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan.;Univ Tsukuba, Inst Med, Dept Genome Biol, Tsukuba, Ibaraki 3058575, Japan.;Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland.
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- MacKay, Matthew J. (author)
- Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.;Weill Cornell Med, WorldQuant Initiat Quantitat Predict, New York, NY 10065 USA.
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- Cope, Henry (author)
- Univ Nottingham, Sch Med, Nottingham DE22 3DT, England.
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- Szewczyk, Nathaniel J. (author)
- Univ Nottingham, Sch Med, Nottingham DE22 3DT, England.;Ohio Univ, Heritage Coll Osteopath Med, OMNI, Athens, OH 45701 USA.
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- Kim, Jangkeun (author)
- Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.
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- Overbey, Eliah (author)
- Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.
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- Tierney, Braden T. (author)
- Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.
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- Muratani, Masafumi (author)
- Univ Tsukuba, Transborder Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan.;Univ Tsukuba, Inst Med, Dept Genome Biol, Tsukuba, Ibaraki 3058575, Japan.
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- Lamm, Ben (author)
- Colossal Biosci, 1401 Lavaca St,Unit 155 Austin, Austin, TX 78701 USA.
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- Bezdan, Daniela (author)
- Univ Tubingen, Inst Med Genet & Appl Genom, Tubingen, Germany.;Univ Tubingen, NCCT, Tubingen, Germany.;Yuri GmbH, Meckenbeuren, Germany.
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- Paul, Amber M. (author)
- Embry Riddle Aeronaut Univ, Dept Human Factors & Behav Neurobiol, Daytona Beach, FL 32114 USA.
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- Schmidt, Michael A. (author)
- Sovaris Aerosp, Boulder, CO 80302 USA.;Adv Pattern Anal & Human Performance Grp, Boulder, CO 80302 USA.
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- Church, George M. (author)
- GC Therapeut Inc, Cambridge, MA 02139 USA.;Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.;Harvard Univ, Wyss Inst Biologically Inspired Engn, Cambridge, MA 02115 USA.
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- Giacomello, Stefania (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Mason, Christopher E. (author)
- Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.;Weill Cornell Med, WorldQuant Initiat Quantitat Predict, New York, NY 10065 USA.;Harvard Univ, Wyss Inst Biologically Inspired Engn, Cambridge, MA 02115 USA.;Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY 10065 USA.
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Univ Tsukuba, Transborder Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan;Univ Tsukuba, Inst Med, Dept Genome Biol, Tsukuba, Ibaraki 3058575, Japan.;Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland. Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA.;Weill Cornell Med, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA.;Weill Cornell Med, WorldQuant Initiat Quantitat Predict, New York, NY 10065 USA. (creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health. Although some technical and ethical challenges remain, research into these protective mechanisms could translate into improved nutrition, exercise, and health recommendations for crew members during deep space missions. As space travel promises to become a reality for more humans, insights from human genetics could serve to inform space medicine. Here, the authors overview genetic variants that might confer a protective effect in space, and ethical and technical challenges to translating these findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Rutter, Lindsay ...
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MacKay, Matthew ...
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Cope, Henry
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Szewczyk, Nathan ...
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Kim, Jangkeun
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Overbey, Eliah
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show more...
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Tierney, Braden ...
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Muratani, Masafu ...
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Lamm, Ben
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Bezdan, Daniela
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Paul, Amber M.
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Schmidt, Michael ...
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Church, George M ...
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Giacomello, Stef ...
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Mason, Christoph ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Communica ...
- By the university
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Royal Institute of Technology