Search: onr:"swepub:oai:DiVA.org:kth-8256" >
A whole-genome bioi...
A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation
-
- Berglund, Lisa (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Björling, Erik (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Jonasson, Kalle (author)
- KTH,Skolan för bioteknologi (BIO)
-
show more...
-
- Rockberg, Johan, 1979- (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Fagerberg, Linn (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Al-Khalili Szigyarto, Cristina (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Sivertsson, Åsa (author)
- KTH,Skolan för bioteknologi (BIO)
-
- Uhlén, Mathias (author)
- KTH,Skolan för bioteknologi (BIO)
-
show less...
-
(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
-
In: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 8:14, s. 2832-2839
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Here, we present an antigen selection strategy based on a whole-genome bioinformatics approach, which is facilitated by an interactive visualization tool displaying protein features from both public resources and in-house generated data. The web-based bioinformatics platform has been designed for selection of multiple, non-overlapping recombinant protein epitope signature tags by display of predicted information relevant for antigens, including domain- and epitope sized sequence similarities to other proteins, transmembrane regions and signal peptides. The visualization tool also displays shared and exclusive protein regions for genes with multiple splice variants. A genome-wide analysis demonstrates that antigens for approximately 80% of the human protein-coding genes can be selected with this strategy.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Keyword
- antibody generation
- antigen selection
- bioinformatics
- epitope
- sequence similarity
- CELL EPITOPE PREDICTION
- HUMAN PROTEOME
- B-CELL
- DETERMINANTS
- EXPRESSION
- PROTEINS
- PROGRAM
- SITES
- ATLAS
- GENE
- Bioengineering
- Bioteknik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Proteomics
(Search for host publication in LIBRIS)
To the university's database