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  • Busenlehner, L.S. (author)

Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1

  • Article/chapterEnglish2004

Publisher, publication year, extent ...

  • 2004-08-12
  • American Chemical Society (ACS),2004
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-82977
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-82977URI
  • https://doi.org/10.1021/bi048716kDOI
  • https://lup.lub.lu.se/record/139377URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:110466629URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20120224
  • Microsomal glutathione (GSH) transferase 1 (MGST1) is a trimeric, integral membrane protein involved in cellular response to chemical or oxidative stress. The cytosolic domain of MGST1 harbors the GSH binding site and a cysteine residue (C49) that acts as a sensor of oxidative and chemical stress. Spatially resolved changes in the kinetics of backbone amide H/D exchange reveal that the binding of a single molecule of GSH/trimer induces a cooperative conformational transition involving movements of the transmembrane helices and a reordering of the cytosolic domain. Alkylation of the stress sensor preorganizes the helices and facilitates the cooperative transition resulting in catalytic activation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Codreanu, S.G. (author)
  • Holm, P.J. (author)
  • Bhakat, P. (author)
  • Hebert, HansLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Karolinska Institutet,Strukturell bioteknik(Swepub:lu)mbfy-hhe (author)
  • Morgenstern, R.Karolinska Institutet (author)
  • Armstrong, R.N. (author)
  • Biokemi och StrukturbiologiCentrum för Molekylär Proteinvetenskap (creator_code:org_t)

Related titles

  • In:Biochemistry: American Chemical Society (ACS)43:35, s. 11145-111520006-29601520-4995

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