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Regulation of thala...
Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
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- Granseth, Björn, 1973- (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Osaka University, Suita, Japan
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- Fukushima, Yuichi (författare)
- Osaka University, Suita, Japan
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- Sugo, Noriuki (författare)
- Osaka University, Suita, Japan
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- Lagnado, Leon (författare)
- Osaka University, Suita, Japan
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- Yamamoto, Nobuhiko (författare)
- Osaka University, Suita, Japan
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: Frontiers in Neural Circuits. - : Frontiers Media SA. - 1662-5110. ; 7:202
- Relaterad länk:
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- During development, axons form branches in response to extracellular molecules. Little is known about the underlying molecular mechanisms. Here, we investigate how neurotrophin-induced axon branching is related to synaptic vesicle cycling for thalamocortical axons. The exogenous application of brain-derived neurotrophic factor (BDNF) markedly increased axon branching in thalamocortical co-cultures, while removal of endogenous BDNF reduced branching. Over-expression of a C-terminal fragment of AP180 that inhibits clathrin-mediated endocytosis affected the laminar distribution and the number of branch points. A dominant-negative synaptotagmin mutant that selectively targets synaptic vesicle cycling, strongly suppressed axon branching. Moreover, axons expressing the mutant synaptotagmin were resistant to the branch-promoting effect of BDNF. These results suggest that synaptic vesicle cycling might regulate BDNF induced branching during the development of the axonal arbor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Neocortex
- development
- BDNF
- neurotrophin
- axon branching
- endocytosis
- exocytosis
- neurotransmitter release
- synapse
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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