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Reduced intensity-c...
Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation
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- Auner, H W. (author)
- University of London Imperial Coll Science Technology and Med, England
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- Szydlo, R (author)
- University of London Imperial Coll Science Technology and Med, England
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- van Biezen, A (author)
- Leiden University, Netherlands
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- Iacobelli, S (author)
- University of Roma Tor Vergata, Italy
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- Gahrton, G (author)
- Karolinska Institutet
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- Milpied, N (author)
- Hop Haut Leveque, France
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- Volin, L (author)
- University of Helsinki, Finland
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- Janssen, J (author)
- Vrije University of Amsterdam, Netherlands
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- Nguyen Quoc, S (author)
- Grp Hospital Pitie Salpetriere, France
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- Michallet, M (author)
- Hop Edouard Herriot, France
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- Schoemans, H (author)
- University Hospital Gasthuisberg, Belgium
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- el Cheikh, J (author)
- Institute J Paoli I Calmettes, France
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- Petersen, E (author)
- University of Medical Centre, Netherlands
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- Guilhot, F (author)
- Hop La Miletrie, France
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- Schoenland, S (author)
- Heidelberg University, Germany
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- Ahlberg, Lucia (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US
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- Morris, C (author)
- Queens University of Belfast, North Ireland
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- Garderet, L (author)
- Hop St Antoine, France
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- de Witte, T (author)
- Radboud University of Nijmegen, Netherlands
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- Kroeger, N (author)
- University Hospital Eppendorf, Germany
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(creator_code:org_t)
- 2013-05-27
- 2013
- English.
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In: Bone Marrow Transplantation. - : Nature Publishing Group: Open Access Hybrid Model Option B. - 0268-3369 .- 1476-5365. ; 48:11, s. 1395-1400
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the treatment of relapse/progression after prior auto-SCT. Median age at RIC allo-SCT was 54.1 years, and 44.6% of patients had undergone two or more prior auto-SCTs. Median OS and PFS from the time of RIC allo-SCT for the entire population were 24.7 and 9.6 months, respectively. Cumulative non-relapse mortality (NRM) at 1 year was 21.5%. In multivariate analysis, CMV seronegativity of both patient and donor was associated with significantly better PFS, OS and NRM. Patient-donor gender mismatch was associated with better PFS, fewer than two prior auto-SCT was associated with better OS, and shorter time from the first auto-SCT to the RIC allo-SCT was associated with lower NRM. The results of this study identify patient and donor CMV seronegativity as the key prognostic factor for outcome after RIC allo-SCT for MM relapsing or progressing after prior auto-SCT.
Keyword
- myeloma
- allogeneic
- stem cell transplantation
- reduced-intensity
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Auner, H W.
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Szydlo, R
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van Biezen, A
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Iacobelli, S
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Gahrton, G
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Milpied, N
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show more...
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Volin, L
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Janssen, J
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Nguyen Quoc, S
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Michallet, M
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Schoemans, H
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el Cheikh, J
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Petersen, E
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Guilhot, F
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Schoenland, S
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Ahlberg, Lucia
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Morris, C
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Garderet, L
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de Witte, T
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Kroeger, N
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show less...
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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Linköping University
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Karolinska Institutet