Sökning: onr:"swepub:oai:DiVA.org:liu-115328" >
BMI is an important...
BMI is an important driver of beta-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children
-
- Lauria, A. (författare)
- University of Campus Biomed, Italy
-
- Barker, A. (författare)
- MRC Epidemiol Unit, England
-
- Schloot, N. (författare)
- University of Dusseldorf, Germany
-
visa fler...
-
- Hosszufalusi, N. (författare)
- Semmelweis Univ, Hungary
-
- Ludvigsson, Johnny (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Barn- och ungdomskliniken i Linköping,Medicinska fakulteten
-
- Mathieu, C. (författare)
- Katholieke University of Leuven, Belgium
-
- Mauricio, D. (författare)
- Hospital Arnau Vilanova, Spain
-
- Nordwall, Maria (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
-
- Van der Schueren, B. (författare)
- Katholieke University of Leuven, Belgium
-
- Mandrup-Poulsen, T. (författare)
- University of Copenhagen, Denmark; Karolinska Institute, Sweden
-
- Scherbaum, W. A. (författare)
- University of Dusseldorf, Germany
-
- Weets, I. (författare)
- VUB, Belgium; VUB, Belgium; BDR, Belgium
-
- Gorus, F. K. (författare)
- VUB, Belgium; VUB, Belgium; BDR, Belgium
-
- Wareham, N. (författare)
- MRC Epidemiol Unit, England
-
- Leslie, R. D. (författare)
- Queen Mary University of London, England
-
- Pozzilli, P. (författare)
- University of Campus Biomed, Italy; Queen Mary University of London, England
-
visa färre...
-
(creator_code:org_t)
- BioScientifica, 2015
- 2015
- Engelska.
-
Ingår i: European Journal of Endocrinology. - : BioScientifica. - 0804-4643 .- 1479-683X. ; 172:2, s. 107-113
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. Design: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. Methods: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (less than5 years, n = 126; greater than5 years less than10 years, n = 295; greater than10 years less than18 years, n = 421; greater than18 years, n = 410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. Results: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed greater than18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (beta 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m(2) higher baseline BMI (P = 0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (beta = 0.026, 95% CI = 0.0097, 0.042; P = 0.002). Conclusions: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of beta-cell function in type 1 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lauria, A.
-
Barker, A.
-
Schloot, N.
-
Hosszufalusi, N.
-
Ludvigsson, John ...
-
Mathieu, C.
-
visa fler...
-
Mauricio, D.
-
Nordwall, Maria
-
Van der Schueren ...
-
Mandrup-Poulsen, ...
-
Scherbaum, W. A.
-
Weets, I.
-
Gorus, F. K.
-
Wareham, N.
-
Leslie, R. D.
-
Pozzilli, P.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet