Search: onr:"swepub:oai:DiVA.org:liu-136869" >
Some Synonymous and...
Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays
-
- Ajileye, Adebisi (author)
- Birmingham Heartlands Hospital, England
-
- Alvarez, Nataly (author)
- Corp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia
-
- Merker, Matthias (author)
- Research Centre Borstel, Germany; German Centre Infect Research, Germany
-
show more...
-
- Walker, Timothy M. (author)
- University of Oxford, England
-
- Akter, Suriya (author)
- Institute Trop Med, Belgium
-
- Brown, Kerstin (author)
- Birmingham Heartlands Hospital, England
-
- Moradigaravand, Danesh (author)
- Wellcome Trust Sanger Institute, England
-
- Schön, Thomas (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Kalmar County Hospital, Sweden
-
- Andres, Soenke (author)
- Research Centre Borstel, Germany
-
- Schleusener, Viola (author)
- Research Centre Borstel, Germany
-
- Omar, Shaheed V. (author)
- Centre TB, South Africa
-
- Coll, Francesc (author)
- London School Hyg and Trop Med, England
-
- Huang, Hairong (author)
- Capital Medical University, Peoples R China
-
- Diel, Roland (author)
- University Hospital, Germany
-
- Ismail, Nazir (author)
- Centre TB, South Africa
-
- Parkhill, Julian (author)
- Wellcome Trust Sanger Institute, Hinxton, United Kingdom
-
- de Jong, Bouke C. (author)
- Institute Trop Med, Belgium
-
- Peto, Tim E. A. (author)
- University of Oxford, England
-
- Crook, Derrick W. (author)
- University of Oxford, England; Public Health England Microbiol Serv, England
-
- Niemann, Stefan (author)
- Research Centre Borstel, Germany; German Centre Infect Research, Germany
-
- Robledo, Jaime (author)
- Corp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia
-
- Grace Smith, E. (author)
- Birmingham Heartlands Hospital, England
-
- Peacock, Sharon J. (author)
- Wellcome Trust Sanger Institute, England; London School Hyg and Trop Med, England; University of Cambridge, England
-
- Koeser, Claudio U. (author)
- University of Cambridge, England
-
show less...
-
(creator_code:org_t)
- AMER SOC MICROBIOLOGY, 2017
- 2017
- English.
-
In: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:4
- Related links:
-
https://liu.diva-por... (primary) (Raw object)
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Mycobacterium tuberculosis; Hain GenoType MTBDRsl; fluoroquinolones
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ajileye, Adebisi
-
Alvarez, Nataly
-
Merker, Matthias
-
Walker, Timothy ...
-
Akter, Suriya
-
Brown, Kerstin
-
show more...
-
Moradigaravand, ...
-
Schön, Thomas
-
Andres, Soenke
-
Schleusener, Vio ...
-
Omar, Shaheed V.
-
Coll, Francesc
-
Huang, Hairong
-
Diel, Roland
-
Ismail, Nazir
-
Parkhill, Julian
-
de Jong, Bouke C ...
-
Peto, Tim E. A.
-
Crook, Derrick W ...
-
Niemann, Stefan
-
Robledo, Jaime
-
Grace Smith, E.
-
Peacock, Sharon ...
-
Koeser, Claudio ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
- Articles in the publication
-
Antimicrobial Ag ...
- By the university
-
Linköping University