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Biomarker Profiles ...
Biomarker Profiles in Heart Failure Patients With Preserved and Reduced Ejection Fraction
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- Tromp, Jasper (author)
- University of Groningen, Netherlands
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- Khan, Mohsin A. F. (author)
- University of Groningen, Netherlands; Academic Medical Centre, Netherlands
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- Klip, IJsbrand T. (author)
- University of Groningen, Netherlands
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- Meyer, Sven (author)
- University of Groningen, Netherlands; Carl von Ossietzky University of Oldenburg, Germany
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- de Boer, Rudolf A. (author)
- University of Groningen, Netherlands
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- Jaarsma, Tiny (author)
- Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten
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- Hillege, Hans (author)
- University of Groningen, Netherlands
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- van Veldhuisen, Dirk J. (author)
- University of Groningen, Netherlands
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- van der Meer, Peter (author)
- University of Groningen, Netherlands
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- Voors, Adriaan A. (author)
- University of Groningen, Netherlands
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(creator_code:org_t)
- WILEY, 2017
- 2017
- English.
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In: Journal of the American Heart Association. - : WILEY. - 2047-9980. ; 6:4
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background-Biomarkers may help us to unravel differences in the underlying pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF). Therefore, we compared biomarker profiles to characterize pathophysiological differences between patients with HFrEF and HFpEF. Methods and Results-We retrospectively analyzed 33 biomarkers from different pathophysiological domains (inflammation, oxidative stress, remodeling, cardiac stretch, angiogenesis, arteriosclerosis, and renal function) in 460 HF patients (21% HFpEF, left ventricular ejection fraction amp;gt;= 45%) measured at discharge after hospitalization for acute HF. The association between these markers and the occurrence of all-cause mortality and/or HF-related rehospitalizations at 18 months was compared between patients with HFrEF and HFpEF. Patients were 70.6 +/- 11.4 years old and 37.4% were female. Patients with HFpEF were older, more often female, and had a higher systolic blood pressure. Levels of high-sensitive C-reactive protein were significantly higher in HFpEF, while levels of pro-atrial-type natriuretic peptide and N-terminal pro-brain natriuretic peptide were higher in HFrEF. Linear regression followed by network analyses revealed prominent inflammation and angiogenesis-associated interactions in HFpEF and mainly cardiac stretch-associated interactions in HrEF. The angiogenesis-specific marker, neuropilin and the remodeling-specific marker, osteopontin were predictive for all-cause mortality and/or HF-related rehospitalizations at 18 months in HFpEF, but not in HFrEF (P for interaction amp;lt;0.05). Conclusions-In HFpEF, inflammation and angiogenesis- mediated interactions are predominantly observed, while stretch-mediated interactions are found in HFrEF. The remodeling marker osteopontin and the angiogenesis marker neuropilin predicted outcome in HFpEF, but not in HFrEF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- biomarker; heart failure; multimarker; pathophysiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tromp, Jasper
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Khan, Mohsin A. ...
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Klip, IJsbrand T ...
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Meyer, Sven
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de Boer, Rudolf ...
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Jaarsma, Tiny
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show more...
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Hillege, Hans
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van Veldhuisen, ...
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van der Meer, Pe ...
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Voors, Adriaan A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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Linköping University