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Macroporous gelatin...
Macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues. : In vivo study in nude mice
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- Huss, Fredrik R.M. (author)
- Östergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US,Inst för Experimentell och Klinisk medicin, Linköping
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- Junker, Johan P.E. (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet,Inst för Experimentell och Klinisk medicin, Linköping
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- Johnson, Hans (author)
- Linköpings universitet,Kirurgi,Hälsouniversitetet,Inst för Experimentell och Klinisk medicin, Linköping
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- Kratz, Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hand och plastikkirurgi,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US,Inst för Experimentell och Klinisk medicin, Linköping
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Journal of Plastic, Reconstructive, and Aesthetic Surgery. - : Elsevier BV. - 1748-6815 .- 1878-0539. ; 60:5, s. 543-555
- Related links:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermally in nude mice gelatine spheres that had either been preseeded with human fibroblasts or preadipocytes, or left unseeded. We compared the extent of regenerated tissue with that found after injections of saline or single-cell suspensions of human fibroblasts or preadipocytes. Routine histological examinations and immunohistochemical staining for von Willebrand factor (indicating neoangiogenesis) were made after 7, 21, and 56 days. Injected saline or single-cell suspensions had no effect. However, a quick and thorough tissue regeneration with developing neoangiogenesis was elicited by the gelatine spheres and the effect of spheres preseeded with preadipocytes surpassed the effect of spheres preseeded with fibroblasts, which in turn surpassed the effect of unseeded gelatine spheres. We suggest that minor soft tissue defects such as wrinkles or creases can be corrected by injection of naked macroporous gelatine spheres, whereas larger defects are best corrected by injection of macroporous gelatine spheres preseeded with fibroblasts, or preadipocytes, or both.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Filler
- Soft tissue defect
- Guided tissue regeneration
- Tissue engineering
- Animal
- In vivo
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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