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- Garvin, Peter,1976-Linköpings universitet,Hälsouniversitetet,Socialmedicin och folkhälsovetenskap (author)
Circulating Matrix Metalloproteinase-9 Is Associated with Cardiovascular Risk Factors in a Middle-Aged Normal Population
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2008-03-12
- Public Library of Science (PLoS),2008
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-14925
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14925URI
- https://doi.org/10.1371/journal.pone.0001774DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Original Publication: Peter Garvin, Lennart Nilsson, John Carstensen, Lena Jonasson and Margareta Kristenson, Circulating Matrix Metalloproteinase-9 Is Associated with Cardiovascular Risk Factors in a Middle-Aged Normal Population, 2008, PLoS ONE, (3), 3, e1774. http://dx.doi.org/10.1371/journal.pone.0001774 Licensee: Public Library of Science (PLoS) http://www.plos.org/
- Background: Elevated levels of circulating matrix metalloproteinase-9 (MMP-9) have been demonstrated in patients with established coronary artery disease (CAD). The aim of this study was to analyse levels of MMP-9 in a population free from symptomatic CAD and investigate their associations with cardiovascular (CV) risk factors, including C-reactive protein (CRP). Methods: A cross-sectional study was performed in a population based random sample aged 45–69 (n = 345, 50% women). MMP-9 levels were measured in EDTA-plasma using an ELISA-method. CV risk factors were measured using questionnaires and standard laboratory methods.Results: Plasma MMP-9 was detectable in all participants, mean 38.9 ng/mL (SD 22.1 ng/mL). Among individuals without reported symptomatic CAD a positive association (p<0.001) was seen, for both men and women, of MMP-9 levels regarding total risk load of eight CV risk factors i.e. blood pressure, dyslipidemia, diabetes, obesity, smoking, alcohol intake, physical activity and fruit and vegetable intake. The association was significant also after adjustment for CRP, and was not driven by a single risk factor alone. In regression models adjusted for age, sex, smoking, alcohol intake and CRP, elevated MMP-9 levels were independently positively associated with systolic blood pressure (p = 0.037), smoking (p<0.001), alcohol intake (p = 0.003) and CRP (p<0.001). The correlation coefficient between MMP-9 and CRP was r = 0.24 (p<0.001). Conclusions: In a population without reported symptomatic CAD, MMP-9 levels were associated with total CV risk load as well as with single risk factors. This was found also after adjustment for CRP
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, LennartÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken(Swepub:liu)lenni29 (author)
- Carstensen, JohnLinköpings universitet,Hälsa och samhälle,Filosofiska fakulteten(Swepub:liu)johca98 (author)
- Jonasson, LenaÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Filosofiska fakulteten,Kardiologiska kliniken(Swepub:liu)lenjo59 (author)
- Kristenson, MargaretaLinköpings universitet,Socialmedicin och folkhälsovetenskap,Hälsouniversitetet,Landstinget i Östergötland; Centre for Public Health Sciences; Centre for Public Health Sciences; Folkhälsovetenskapligt centrum; Folkhälsovetenskapligt centrum(Swepub:liu)markr44 (author)
- Linköpings universitetHälsouniversitetet (creator_code:org_t)
Related titles
- In:PLoS ONE: Public Library of Science (PLoS)3:3, s. e1774-1932-6203
Internet link
- http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14929Link to Ph.D. Thesis
- https://liu.diva-portal.org/smash/get/diva2:25612/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001774&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14925
- https://doi.org/10.1371/journal.pone.0001774
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