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AMPA-selective glutamate receptor subunits and their relation to glutamate-and GABA-like immunoreactive terminals in the nucleus submedius of the rat
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- Hamlin, Lina (författare)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
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- Mackerlova, Ludmila, 1945- (författare)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
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- Blomqvist, Anders, 1949- (författare)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
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- Ericson, Ann-Charlott, 1965- (författare)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
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(creator_code:org_t)
- Elsevier, 1996
- Engelska.
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Ingår i: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 217:2-3, s. 149-52
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glutamate plays an important role in supraspinal nociceptive systems. Thus, glutamate is present in the nucleus submedius of the medial thalamus, a major relay for nociceptive information. In this study, immunoreactivity for the four subunits (GluR1-4) of alpha-amino-3-hydroxy-5-methyl-4-isoxasoleproprionate (AMPA) receptors was examined by a preembedding immunohistochemical method in order to evaluate the presence of this glutamate receptor subtype in the nucleus submedius. Combining the preembedding method with a postembedding immunogold technique, we found that AMPA receptor-like immunoreactivity was present postsynaptically to glutamatergic terminals but not to terminals containing gamma-aminobutyric acid (GABA). These findings suggest a role for AMPA receptors in excitatory synaptic transmission in the nucleus submedius of the rat thalamus.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Receptor
- Glutamate
- Non-N-methyl-d-aspartate
- Pain
- Thalamus
- Electron microscopy
- Postembedding immunohistochemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)