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Increased circulati...
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Persson, MarieLinköpings universitet,Klinisk immunologi,Hälsouniversitetet
(författare)
Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Elsevier BV,2008
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-16134
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16134URI
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https://doi.org/10.1016/j.jri.2008.07.001DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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INTRODUCTION: Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy.AIM: The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout pregnancy.METHODS: Blood samples were collected on six occasions during pregnancy and two occasions postpartum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Eleven women fulfilled the strict criteria for allergy (allergic symptoms and circulating IgE antibodies to inhalant allergens) and 23 were strictly non-allergic (non-sensitized without symptoms). The numbers of blood mononuclear cells secreting IFN-gamma and IL-4, spontaneously and in response to paternal alloantigens, were compared between the groups.RESULTS: The numbers of spontaneously as well as paternal antigen-induced IFN-gamma- and IL-4-secreting cells were similar in allergic and non-allergic pregnant women on all occasions. A similar increase in the numbers of both IFN-gamma- and IL-4-secreting cells were found in allergic and non-allergic women during pregnancy, both regarding spontaneous and paternal antigen-induced secretion.CONCLUSIONS: This study does not support the hypothesis of a more pronounced Th2-deviation to paternal antigens in allergic pregnant women compared with non-allergic pregnant women, as measured by number of cytokine-secreting cells. The observed increase of both IFN-gamma- and IL-4-secreting cells during normal pregnancy may be interpreted as a Th2-situation, since the effects of IL-4 predominate over the effects of IFN-gamma.
Ämnesord och genrebeteckningar
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Pregnancy
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Th2
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Elispot
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MLC
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ekerfelt, ChristinaLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)chrek55
(författare)
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Ernerudh, JanLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)janer15
(författare)
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Matthiesen, LeifÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet(Swepub:liu)leima96
(författare)
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Jenmalm, MariaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18
(författare)
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Jonsson, YvonneLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)yvojo35
(författare)
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Sandberg, MartinaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marsa92
(författare)
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Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet(Swepub:liu)gorbe09
(författare)
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Linköpings universitetKlinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Reproductive Immunology: Elsevier BV79:1, s. 70-780165-03781872-7603
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