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- Ljungberg, Liza,1980-Linköpings universitet,Farmakologi,Hälsouniversitetet,Division of Drug Research/Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping (författare)
Effect of Nicotine and Nicotine Metabolites on Angiotensin-Converting Enzyme in Human Endothelial Cells
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
- 2009-07-13
- Philadelphia, USA :Informa UK Limited,2008
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-16216
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16216URI
- https://doi.org/10.1080/10623320802487627DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42391URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- This is an electronic version of an article published in:Liza Ljungberg and Karin Persson, Effect of Nicotine and Nicotine Metabolites on Angiotensin-Converting Enzyme in Human Endothelial Cells, 2008, Endothelium, (15), 5-6, 239-245.Endothelium is available online at informaworldTM: http://dx.doi.org/10.1080/10623320802487627Copyright: Taylor & Francishttp://www.tandf.co.uk/journals/default.asp
- Nicotine has been shown to induce endothelial dysfunction, which is an early marker of atherosclerosis. Nicotine undergoes extensive metabolism in the liver, forming a number of major and minor metabolites. There are very limited data on the effect of nicotine metabolites on the cardiovascular system. This study investigates the effects of nicotine and the nicotine metabolites, cotinine, cotinine-N-oxide, nicotine-1-N-oxide, norcotinine, trans-3-hydroxycotinine, on angiotensin-converting enzyme (ACE) in human endothelial cells. Cultured endothelial cells obtained from human umbilical cord vein (HUVECs) were stimulated with nicotine or nicotine metabolites in concentrations similar to those observed in plasma during smoking. ACE activity and expression were analyzed using commercial kits. The results showed that nicotine and nicotine metabolites can increase both activity and expression of ACE. However, a marked individual variation in the response to the drugs was observed. This variation was not associated with the ACE insertion/deletion polymorphism. Tobacco contains numerous chemical compounds, and the underlying cause for development of atherosclerosis in smokers is probably multifactorial. The results from this study could explain one cellular mechanism by which smoking exerts negative effect on the vascular system.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- Angiotensin-Converting Enzyme
- Atherosclerosis
- Endothelial Cells
- Nicotine
- Nicotine Metabolites
- Tobacco
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Persson, KarinLinköpings universitet,Farmakologi,Hälsouniversitetet,Division of Drug Research/Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping(Swepub:liu)karpe01 (författare)
- Linköpings universitetFarmakologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:EndotheliumPhiladelphia, USA : Informa UK Limited15:5-6, s. 239-2451062-33291029-2373
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