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Heptapeptide HP3 ac...
Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod-induced murine psoriasis and impedes the trans-endothelial migration of mononuclear cells
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- Vazquez-Sanchez, Ernesto A. (författare)
- Inst Politecn Nacl IPN, Mexico; Escuela Nacl Med and Homeopatia ENMyH IPN, Mexico
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- Mendoza Figueroa, Silvestre (författare)
- Linköpings universitet,Biofysik och bioteknik,Tekniska fakulteten
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- Gutierrez-Gonzalez, Guadalupe (författare)
- Inst Politecn Nacl IPN, Mexico
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- Zapi-Colin, Luis A. (författare)
- Inst Politecn Nacl IPN, Mexico
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- Torales-Cardena, Azael (författare)
- Escuela Nacl Med and Homeopatia ENMyH IPN, Mexico
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- Briseno-Lugo, Paola E. (författare)
- Univ Nacl Autonoma Mexico, Mexico
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- Diaz-toala, Ivan (författare)
- Escuela Super Comp IPN, Mexico
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- Cancino-Diaz, Juan C. (författare)
- ENCB IPN, Mexico
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- Perez-Tapia, Sonia M. (författare)
- ENCB IPN, Mexico
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- Cancino-Diaz, Mario E. (författare)
- Inst Politecn Nacl IPN, Mexico
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- Gomez-Chavez, Fernando (författare)
- Escuela Nacl Med and Homeopatia ENMyH IPN, Mexico; Inst Nacl Pediat, Mexico
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- Rodriguez-Martinez, Sandra (författare)
- Inst Politecn Nacl IPN, Mexico
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(creator_code:org_t)
- 2020-05-05
- 2020
- Engelska.
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Ingår i: Molecular Medicine Reports. - : SPANDIDOS PUBL LTD. - 1791-2997 .- 1791-3004. ; 22:1, s. 507-515
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- During the progression of psoriatic lesions, abundant cellular infiltration of myeloid cells, such as macrophages and activated dendritic cells, occurs in the skin and the infiltrating cells interact with naive lymphoid cells to generate a T helper (Th)1 and Th17 environment. Therapies to treat psoriasis include phototherapy, non-steroidal and steroidal drugs, as well as antibodies to block tumor necrosis factor-alpha, interleukin (IL)-17-A and IL-12/IL-23, which all focus on decreasing the proinflammatory hallmark of psoriasis. The present study obtained the heptapeptide HP3 derived from phage display technology that blocks mononuclear cell adhesion to endothelial cells and inhibits trans-endothelial migrationin vitro. The activity of the heptapeptide in a murine model of psoriasis was also assessed, which indicated that early administration inhibited the development of psoriatic lesions. Therefore, the results suggested that HP3 may serve as a potential therapeutic target for psoriasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- psoriasis; peptide; phage display; inflammation; treatment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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