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Harnessing Selectiv...
Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor
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- Parkula, Vitaliy (author)
- Univ Modena & Reggio Emilia, Italy; Scriba Nanotecnol Srl, Italy
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- Berto, Marcello (author)
- Univ Modena & Reggio Emilia, Italy
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- Diacci, Chiara (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Univ Modena & Reggio Emilia, Italy
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- Patrahau, Bianca (author)
- Univ Modena & Reggio Emilia, Italy; Univ Strasbourg, France
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- Di Lauro, Michele (author)
- Univ Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy
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- Kovtun, Alessandro (author)
- CNR, Italy
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- Liscio, Andrea (author)
- CNR, Italy
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- Sensi, Matteo (author)
- Univ Modena & Reggio Emilia, Italy
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- Samori, Paolo (author)
- Univ Strasbourg, France
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- Greco, Pierpaolo (author)
- Scriba Nanotecnol Srl, Italy
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- Bortolotti, Carlo A. (author)
- Univ Modena & Reggio Emilia, Italy
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- Biscarini, Fabio (author)
- Univ Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy
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(creator_code:org_t)
- 2020-06-02
- 2020
- English.
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In: Analytical Chemistry. - : AMER CHEMICAL SOC. - 0003-2700 .- 1520-6882. ; 92:13, s. 9330-9337
- Related links:
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 mu L microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNF alpha, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Parkula, Vitaliy
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Berto, Marcello
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Diacci, Chiara
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Patrahau, Bianca
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Di Lauro, Michel ...
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Kovtun, Alessand ...
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show more...
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Liscio, Andrea
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Sensi, Matteo
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Samori, Paolo
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Greco, Pierpaolo
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Bortolotti, Carl ...
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Biscarini, Fabio
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
- Articles in the publication
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Analytical Chemi ...
- By the university
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Linköping University