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Immune-mediated feb...
Immune-mediated febrile response in female rats: Role of central hypothalamic mediators
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- Brito, Haissa Oliveira (author)
- Univ Fed Parana, Brazil
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- Radulski, Debora (author)
- Univ Fed Parana, Brazil
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- Wilhelms, Daniel (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Akutkliniken i Linköping
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- Stojakovic, Andrea (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Oliveira Brito, Luciane Maria (author)
- Univ Fed Maranhao, Brazil
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- Gil da Costa, Rui Miguel (author)
- Univ Fed Maranhao, Brazil
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- Trindade, Edvaldo (author)
- Univ Fed Parana, Brazil
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- Engblom, David (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Cavichiolo Franco, Celia Regina (author)
- Univ Fed Parana, Brazil
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- Zampronio, Aleksander Roberto (author)
- Univ Fed Parana, Brazil
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(creator_code:org_t)
- 2020-03-05
- 2020
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor kappa B ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (SP) and endogenous opioids. LPS-induced fever is reduced in females compared with males except in ovariectomized (OVX) females which show increased fever mediated by PG. The present study aimed to identify the mediators involved in fever in intact and OVX female rats. Fever was induced with LPS (50 mu g/kg) intraperitoneally or CRF (2.5 mu g), ET-1 (1 pg), morphine (10 mu g) and SP (500 ng) intracerebroventricularly in sham-operated and OVX rats. The role of RANKL was evaluated with osteoprotegerin (OPG, 1 mu g, intracerebroventricularly). Expression of RANK, CRFI/II, ETB, mu-opioid (MOR) and NK1 receptors was evaluated by confocal microscopy. Besides LPS, only morphine induced fever in OVX rats while all mediators induced fever in sham-operated animals. OPG abolished LPS-induced fever in OVX but not sham-operated animals. Overall, fever involves similar central mediators in cycling females and males but only morphine induced fever in OVX females. Importantly, RANK/RANKL participates in LPS-induced fever in OVX females, as in males but not in cycling females.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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