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Induction of aquapo...
Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes
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- Tsymala, Irina (author)
- Med Univ Vienna, Austria
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- Nigritinou, Magdalini (author)
- Med Univ Vienna, Austria
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- Zeka, Bleranda (author)
- Med Univ Vienna, Austria
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- Schulz, Rouven (author)
- Med Univ Vienna, Austria
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- Niederschick, Felix (author)
- Med Univ Vienna, Austria
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- Matkovic, Mia (author)
- Med Univ Vienna, Austria
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- Bauer, Isabel J. (author)
- Med Univ Vienna, Austria
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- Szalay, Michael (author)
- Med Univ Vienna, Austria
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- Schanda, Kathrin (author)
- Med Univ Innsbruck, Austria
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- Lerch, Magdalena (author)
- Med Univ Innsbruck, Austria
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- Misu, Tatsuro (author)
- Tohoku Univ, Japan; Tohoku Univ, Japan
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- Fujihara, Kazuo (author)
- Tohoku Univ, Japan; Tohoku Univ, Japan
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- Bennett, Jeffrey L. (author)
- Univ Colorado, CO 80045 USA
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- Dahle, Charlotte, 1956- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Pache, Florence (author)
- Charite Univ Med Berlin, Germany
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- Rommer, Paulus (author)
- Med Univ Vienna, Austria
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- Leutmezer, Fritz (author)
- Med Univ Vienna, Austria
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- Illes, Zsolt (author)
- Odense Univ Hosp, Denmark; Univ Southern Denmark, Denmark
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- Leite, Maria Isabel (author)
- John Radcliffe Hosp, England
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- Palace, Jacqueline (author)
- John Radcliffe Hosp, England
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- Scholze, Petra (author)
- Med Univ Vienna, Austria
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- Reindl, Markus (author)
- Med Univ Innsbruck, Austria
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- Lassmann, Hans (author)
- Med Univ Vienna, Austria
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- Bradl, Monika (author)
- Med Univ Vienna, Austria
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(creator_code:org_t)
- 2020-04-15
- 2020
- English.
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In: Acta neuropathologica communications. - : BMC. - 2051-5960. ; 8:1
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://actaneurocom...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the formation of large tissue destructive lesions in the central nervous system (CNS). Consequently, untreated patients may become permanently blind or paralyzed. Studies on the induction and breakage of tolerance to AQP4 could be of great benefit for NMOSD patients. So far, however, all attempts to create suitable animal models by active sensitization have failed. We addressed this challenge and identified peptides, which mimic the conformational AQP4 epitopes recognized by pathogenic antibodies of NMOSD patients. Here we show that these mimotopes can induce the production of AQP4-reactive antibodies in Lewis rats. Hence, our results provide a conceptual framework for the formation of such antibodies in NMOSD patients, and aid to improve immunization strategies for the creation of animal models suitable for tolerance studies in this devastating disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Neuromyelitis optica spectrum disorders; Antibodies; Mimotopes; Aquaporin 4; Infections; Animal model
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tsymala, Irina
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Nigritinou, Magd ...
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Zeka, Bleranda
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Schulz, Rouven
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Niederschick, Fe ...
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Matkovic, Mia
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show more...
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Bauer, Isabel J.
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Szalay, Michael
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Schanda, Kathrin
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Lerch, Magdalena
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Misu, Tatsuro
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Fujihara, Kazuo
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Bennett, Jeffrey ...
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Dahle, Charlotte ...
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Pache, Florence
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Rommer, Paulus
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Leutmezer, Fritz
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Illes, Zsolt
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Leite, Maria Isa ...
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Palace, Jacqueli ...
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Scholze, Petra
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Reindl, Markus
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Lassmann, Hans
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Bradl, Monika
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Acta neuropathol ...
- By the university
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Linköping University