Sökning: onr:"swepub:oai:DiVA.org:liu-174475" > Higher vs Lower Dos...
Fältnamn | Indikatorer | Metadata |
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000 | 07502naa a2200877 4500 | |
001 | oai:DiVA.org:liu-174475 | |
003 | SwePub | |
008 | 210321s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146058114 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1744752 URI |
024 | 7 | a https://doi.org/10.1111/aas.137932 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460581142 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Granholm, Andersu Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
245 | 1 0 | a Higher vs Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis |
264 | c 2021-02-25 | |
264 | 1 | b WILEY,c 2021 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Novo Nordisk FoundationNovo Nordisk Foundation [0062998]; Rigshospitalets Research Council [E-22703-06] | |
520 | a Background Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates the effects of higher vs lower doses of dexamethasone (12 vs 6 mg intravenously daily for up to 10 days) in 1,000 adult patients with COVID-19 and severe hypoxia. Methods This protocol outlines the rationale and statistical methods for a secondary, pre-planned Bayesian analysis of the primary outcome (days alive without life support at day 28) and all secondary outcomes registered up to day 90. We will use hurdle-negative binomial models to estimate the mean number of days alive without life support in each group and present results as mean differences and incidence rate ratios with 95% credibility intervals (CrIs). Additional count outcomes will be analysed similarly and binary outcomes will be analysed using logistic regression models with results presented as probabilities, relative risks and risk differences with 95% CrIs. We will present probabilities of any benefit/harm, clinically important benefit/harm and probabilities of effects smaller than pre-defined clinically minimally important differences for all outcomes analysed. Analyses will be adjusted for stratification variables and conducted using weakly informative priors supplemented by sensitivity analyses using sceptic priors. Discussion This secondary, pre-planned Bayesian analysis will supplement the primary, conventional analysis and may help clinicians, researchers and policymakers interpret the results of the COVID STEROID 2 trial while avoiding arbitrarily dichotomised interpretations of the results. Trial registration ClinicalTrials.gov: NCT04509973; EudraCT: 2020-003363-25. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Munch, Marie Warreru Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
700 | 1 | a Myatra, Sheila Nainanu Tata Mem Hosp, India4 aut |
700 | 1 | a Vijayaraghavan, Bharath Kumar Tirupakuzhiu Apollo Hosp, India; Chennai Crit Care Consultants, India; Univ New South Wales, India4 aut |
700 | 1 | a Cronhjort, Mariau Karolinska Institutet,Karolinska Inst, Sweden4 aut |
700 | 1 | a Wahlin, Rebecka Rubensonu Karolinska Institutet,Karolinska Inst, Sweden4 aut |
700 | 1 | a Jakob, Stephan M.u Univ Bern, Switzerland4 aut |
700 | 1 | a Cioccari, Lucau Univ Bern, Switzerland4 aut |
700 | 1 | a Kjaer, Maj-Brit Norregaardu Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
700 | 1 | a Vesterlund, Gitte Kingou Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
700 | 1 | a Meyhoff, Tine Sylvestu Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
700 | 1 | a Helleberg, Marieu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Moller, Morten Hylanderu Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
700 | 1 | a Benfield, Thomasu Copenhagen Univ Hosp Amager & Hvidovre, Denmark4 aut |
700 | 1 | a Venkatesh, Balasubramanianu Univ New South Wales, Australia4 aut |
700 | 1 | a Hammond, Naomiu Univ New South Wales, Australia4 aut |
700 | 1 | a Chew, Michelle S,d 1969-u Linköpings universitet,Medicinska fakulteten,Avdelningen för klinisk kemi och farmakologi,Region Östergötland, ANOPIVA US4 aut0 (Swepub:liu)micch61 |
700 | 1 | a Bassi, Abhinavu Univ New South Wales, India4 aut |
700 | 1 | a John, Oommenu Univ New South Wales, India; Manipal Acad Higher Educ, India4 aut |
700 | 1 | a Jha, Vivekanandu Univ New South Wales, India; Manipal Acad Higher Educ, India; Imperial Coll London, England4 aut |
700 | 1 | a Kristiansen, Klaus Tjelleu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Ulrik, Charlotte Suppliu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Lind Jorgensen, Vibekeu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Smitt, Margitu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Bestle, Morten H.u Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark4 aut |
700 | 1 | a Andreasen, Anne Sofieu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Poulsen, Lone Musaeusu Zealand Univ Hosp, Denmark4 aut |
700 | 1 | a Rasmussen, Bodil Steenu Collaborat Res Intens Care CRIC, Denmark; Aalborg Univ Hosp, Denmark4 aut |
700 | 1 | a Brochner, Anne Craveirou Kolding Cty Hosp, Denmark4 aut |
700 | 1 | a Strom, Thomasu Odense Univ Hosp, Denmark; Univ Hosp Southern Denmark, Denmark4 aut |
700 | 1 | a Moller, Andersu Naestved Slagelse Ringsted Hosp, Denmark4 aut |
700 | 1 | a Khan, Mohd Saifu Rajendra Inst Med Sci, India4 aut |
700 | 1 | a Padmanaban, Ajayu Apollo Hosp, India4 aut |
700 | 1 | a Divatia, Jigeeshu Vasishthau Tata Mem Hosp, India4 aut |
700 | 1 | a Saseedharan, Sanjithu SL Raheja Hosp, India4 aut |
700 | 1 | a Borawake, Kapilu Vishwaraj Hosp, India4 aut |
700 | 1 | a Kapadia, Farhadu Hinduja Hosp, India4 aut |
700 | 1 | a Dixit, Subhalu Sanjeevan Hosp, India4 aut |
700 | 1 | a Chawla, Rajeshu Indraprastha Apollo Hosp, India4 aut |
700 | 1 | a Shukla, Urviu Symbiosis Univ Hosp & Res Ctr, India4 aut |
700 | 1 | a Amin, Pravinu Bombay Hosp Inst Med Sci, India4 aut |
700 | 1 | a Chew, Michelle S,d 1969-u Linköpings universitet,Medicinska fakulteten,Avdelningen för klinisk kemi och farmakologi,Region Östergötland, ANOPIVA US4 aut0 (Swepub:liu)micch61 |
700 | 1 | a Gluud, Christianu Copenhagen Univ Hosp, Denmark4 aut |
700 | 1 | a Lange, Theisu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Perner, Andersu Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmark4 aut |
710 | 2 | a Univ Copenhagen, Denmark; Collaborat Res Intens Care CRIC, Denmarkb Tata Mem Hosp, India4 org |
773 | 0 | t Acta Anaesthesiologica Scandinavicad : WILEYg 65:5, s. 702-710q 65:5<702-710x 0001-5172x 1399-6576 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aas.13793 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174475 |
856 | 4 8 | u https://doi.org/10.1111/aas.13793 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146058114 |
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