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Targeted Chemothera...
Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump
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- Waldherr, Linda (author)
- Med Univ Graz, Austria
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- Seitanidou, Maria S (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Jakesova, Marie (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Handl, Verena (author)
- Med Univ Graz, Austria
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- Honeder, Sophie (author)
- Med Univ Graz, Austria
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- Nowakowska, Marta (author)
- Med Univ Graz, Austria
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- Tomin, Tamara (author)
- Med Univ Graz, Austria; Tech Univ Wien, Austria
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- Karami Rad, Meysam (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Schmidt, Tony (author)
- Med Univ Graz, Austria
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- Distl, Joachim (author)
- Med Univ Graz, Austria
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- Birner-Gruenberger, Ruth (author)
- Med Univ Graz, Austria; Tech Univ Wien, Austria
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- Campe, Gord (author)
- Med Univ Graz, Austria
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- Schafer, Ute (author)
- Med Univ Graz, Austria
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- Berggren, Magnus (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Rinner, Beate (author)
- Med Univ Graz, Austria
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- Asslaber, Martin (author)
- Med Univ Graz, Austria
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- Ghaffari-Tabrizi-Wizsy, Nassim (author)
- Med Univ Graz, Austria
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- Patz, Silke (author)
- Med Univ Graz, Austria
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- Simon, Daniel (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Schindl, Rainer (author)
- Med Univ Graz, Austria
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(creator_code:org_t)
- 2021-04-12
- 2021
- English.
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In: Advanced Materials Technologies. - : Wiley. - 2365-709X. ; 6:5
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Successful treatment of glioblastoma multiforme (GBM), the most lethal tumor of the brain, is presently hampered by (i) the limits of safe surgical resection and (ii) "shielding" of residual tumor cells from promising chemotherapeutic drugs such as Gemcitabine (Gem) by the blood brain barrier (BBB). Here, the vastly greater GBM cell-killing potency of Gem compared to the gold standard temozolomide is confirmed, moreover, it shows neuronal cells to be at least 10(4)-fold less sensitive to Gem than GBM cells. The study also demonstrates the potential of an electronically-driven organic ion pump ("GemIP") to achieve controlled, targeted Gem delivery to GBM cells. Thus, GemIP-mediated Gem delivery is confirmed to be temporally and electrically controllable with pmol min(-1) precision and electric addressing is linked to the efficient killing of GBM cell monolayers. Most strikingly, GemIP-mediated GEM delivery leads to the overt disintegration of targeted GBM tumor spheroids. Electrically-driven chemotherapy, here exemplified, has the potential to radically improve the efficacy of GBM adjuvant chemotherapy by enabling exquisitely-targeted and controllable delivery of drugs irrespective of whether these can cross the BBB.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- electrophoretic drug delivery; gemcitabine; glioblastoma multiforme; organic electronic ion pumps
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Waldherr, Linda
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Seitanidou, Mari ...
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Jakesova, Marie
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Handl, Verena
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Honeder, Sophie
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Nowakowska, Mart ...
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show more...
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Tomin, Tamara
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Karami Rad, Meys ...
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Schmidt, Tony
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Distl, Joachim
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Birner-Gruenberg ...
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Campe, Gord
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Schafer, Ute
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Berggren, Magnus
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Rinner, Beate
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Asslaber, Martin
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Ghaffari-Tabrizi ...
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Patz, Silke
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Simon, Daniel
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Schindl, Rainer
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Advanced Materia ...
- By the university
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Linköping University