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Once-weekly oral me...
Once-weekly oral medication with alendronate does not prevent migration of knee prostheses : A double-blind randomized RSA study
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- Hansson, Ulrik (author)
- Lund University Hospital, Sweden
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- Toksvig-Larsen, Sören (author)
- Lund University Hospital, Sweden
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- Ryd, Leif (author)
- Karolinska University Hospital, Huddinge, Sweden
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- Aspenberg, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken Linköping
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(creator_code:org_t)
- 2009-07-08
- 2009
- English.
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In: Acta Orthopaedica. - : Informa Healthcare. - 1745-3674 .- 1745-3682. ; 80:1, s. 41-45
- Related links:
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background and purposeEarly migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement.Patients and methodsWe recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.ResultsThere was no difference in migration of implants between the two groups.ConclusionWith uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.
Publication and Content Type
- ref (subject category)
- art (subject category)
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