Sökning: onr:"swepub:oai:DiVA.org:liu-185003" > Serum hormone level...
Fältnamn | Indikatorer | Metadata |
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000 | 04592naa a2200517 4500 | |
001 | oai:DiVA.org:liu-185003 | |
003 | SwePub | |
008 | 220517s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1850032 URI |
024 | 7 | a https://doi.org/10.1007/s10549-022-06600-92 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sherman, Mark E.u Mayo Clin, FL, USA4 aut |
245 | 1 0 | a Serum hormone levels and normal breast histology among premenopausal women |
264 | c 2022-05-03 | |
264 | 1 | a New York, NY, United States :b Springer,c 2022 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies: Mayo Clinic Cancer Center [P30CA15083-45] | |
520 | a Purpose Breast terminal duct lobular units (TDLUs) are the main source of breast cancer (BC) precursors. Higher serum concentrations of hormones and growth factors have been linked to increased TDLU numbers and to elevated BC risk, with variable effects by menopausal status. We assessed associations of circulating factors with breast histology among premenopausal women using artificial intelligence (AI) and preliminarily tested whether parity modifies associations.Methods Pathology AI analysis was performed on 316 digital images of H&E-stained sections of normal breast tissues from Komen Tissue Bank donors ages ≤ 45 years to assess 11 quantitative metrics. Associations of circulating factors with AI metrics were assessed using regression analyses, with inclusion of interaction terms to assess effect modification.Results Higher prolactin levels were related to larger TDLU area (p<0.001) and increased presence of adipose tissue proximate to TDLUs (p<0.001), with less significant positive associations for acini counts (p = 0.012), dilated acini (p = 0.043), capillary area (p = 0.014), epithelial area (p = 0.007), and mononuclear cell counts (p = 0.017). Testosterone levels were associated with increased TDLU counts (p<0.001), irrespective of parity, but associations differed by adipose tissue content. AI data for TDLU counts generally agreed with prior visual assessments.Conclusion Among premenopausal women, serum hormone levels linked to BC risk were also associated with quantitative features of normal breast tissue. These relationships were suggestively modified by parity status and tissue composition. We conclude that the microanatomic features of normal breast tissue may represent a marker of BC risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Breast cancer risk; Terminal duct lobular units; Hormones; Normal breast tissue | |
700 | 1 | a de Bel, Thomasu Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 aut |
700 | 1 | a Heckman, Michael G.u Mayo Clin, FL, USA4 aut |
700 | 1 | a White, Launia J.u Mayo Clin, FL, USA4 aut |
700 | 1 | a Ogony, Joshuau Mayo Clin, FL, USA4 aut |
700 | 1 | a Stallings-Mann, Melodyu Mayo Clin, FL, USA4 aut |
700 | 1 | a Hilton, Tracyu Mayo Clin, FL, USA4 aut |
700 | 1 | a Degnim, Amy C.u Mayo Clin, MN, USA4 aut |
700 | 1 | a Vierkant, Robert A.u Mayo Clin, MN, USA4 aut |
700 | 1 | a Hoskin, Tanyau Mayo Clin, MN, USA4 aut |
700 | 1 | a Jensen, Matthew R.u Mayo Clin, MN, USA4 aut |
700 | 1 | a Pacheco-Spann, Laurau Mayo Clin, FL, USA4 aut |
700 | 1 | a Henry, Jill E.u Indiana Univ Sch Med, IN, USA4 aut |
700 | 1 | a Storniolo, Anna Mariau Indiana Univ Sch Med, IN, USA4 aut |
700 | 1 | a Carter, Jodi M.u Mayo Clin, MN 55905 USA4 aut |
700 | 1 | a Winham, Stacey J.u Mayo Clin, MN, USA4 aut |
700 | 1 | a Radisky, Derek C.u Mayo Clin, FL, USA4 aut |
700 | 1 | a van der Laak, Jeroen,d 1967-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 aut0 (Swepub:liu)jerva26 |
710 | 2 | a Mayo Clin, FL, USAb Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 org |
773 | 0 | t Breast Cancer Research and Treatmentd New York, NY, United States : Springerg 194, s. 149-158q 194<149-158x 0167-6806x 1573-7217 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185003 |
856 | 4 8 | u https://doi.org/10.1007/s10549-022-06600-9 |
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