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The significance of...
The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patients
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- Jamali, Elham (author)
- Shiraz Univ Med Sci, Iran; Peyvand Pathobiol & Genet Lab, Iran
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- Abbasi, Mojdeh (author)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Shiraz Univ Med Sci, Iran
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- Tayer, Akbar Hashemi (author)
- Jahrom Univ Med Sci, Iran
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- Monfared, Ali Arabi (author)
- Shiraz Univ Med Sci, Iran
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- Tandel, Parisa (author)
- Shiraz Univ Med Sci, Iran
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- Tamaddon, Gholamhossein (author)
- Shiraz Univ Med Sci, Iran
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- Kazerooni, Ehsan Sarraf (author)
- Shiraz Univ Med Sci, Iran
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- Rakhshandehroo, Shahrokh (author)
- Peyvand Pathobiol & Genet Lab, Iran
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- Ranjbaran, Reza (author)
- Shiraz Univ Med Sci, Iran
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022
- 2022
- English.
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In: Blood Cells, Molecules & Diseases. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1079-9796 .- 1096-0961. ; 96
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Inflammatory response-induced coagulopathy is a common complication associated with severe form of covid-19 infection. Evidences suggest that neutrophil extracellular traps (NETs) play a significant role in triggering the immunothrombosis in this condition. We aimed to evaluate the diagnostic value of surface neutrophilic myeloperoxidase (MPO) as NETosis biomarker for predicting the risk of covid-19-associated coagulopathies.Methods: Covid-19 infection was assessed by real-time-PCR and plasma d-dimer levels were measured by ELFA. Based on the covid-19 infection and d-dimer level outcomes, patients were categorized into four groups. Any alteration in the serum level of IL-6, H3Cit and neutrophilic surface MPO were analyzed by CLIA, ELISA, and flow cytometry, respectively.Results: H3Cit variations and different d-dimer values confirmed the association between NETosis and coagu-lopathies. Findings showed that the expression of neutrophilic MPO reduced in cases with NETosis, which was correlated with increased levels of H3Cit. ANC/MPO ratio was signified as a valuable marker to discriminate the covid-19 and non covid-19-associated coagulopathies and could be considered as a prognostic factor due to its noteworthy correlation with serum IL-6 concentration.Conclusion: Declined levels of surface neutrophilic MPO in NETosis correlate with covid-19-associated coagu-lopathies and increased IL-6 levels, as a potential biomarker of covid-19 disease severity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Surface myeloperoxidase; NETosis; Coagulopathies
Publication and Content Type
- ref (subject category)
- art (subject category)
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Jamali, Elham
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Abbasi, Mojdeh
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Tayer, Akbar Has ...
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Monfared, Ali Ar ...
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Tandel, Parisa
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Tamaddon, Gholam ...
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Kazerooni, Ehsan ...
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Rakhshandehroo, ...
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Ranjbaran, Reza
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood Cells, Mol ...
- By the university
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Linköping University