Sökning: onr:"swepub:oai:DiVA.org:liu-18830" > Comparison of Effic...
Fältnamn | Indikatorer | Metadata |
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000 | 03639naa a2200385 4500 | |
001 | oai:DiVA.org:liu-18830 | |
003 | SwePub | |
008 | 090605s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-188302 URI |
024 | 7 | a https://doi.org/10.1016/j.amjcard.2008.10.0292 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tikkanen, M.J.u Helsinki University Central Hospital4 aut |
245 | 1 0 | a Comparison of Efficacy and Safety of Atorvastatin (80 mg) to Simvastatin (20 to 40 mg) in Patients Aged less than65 Versus =65 Years With Coronary Heart Disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] Study) |
264 | 1 | b Elsevier BV,c 2009 |
338 | a print2 rdacarrier | |
520 | a The efficacy and safety of atorvastatin (80 mg/day) versus simvastatin (20 to 40 mg/day) in older (age =65 years) versus younger (less than65 years) patients were assessed in a prespecified secondary analysis of the 8,888 patients with myocardial infarction in the IDEAL trial, a randomized open-label study. Several cardiovascular end points were evaluated, including the occurrence of a first major coronary event (MCE; nonfatal myocardial infarction, coronary heart disease death, or resuscitated cardiac arrest), the primary end point of the trial, and occurrence of any cardiovascular event (MCE, stroke, revascularization, unstable angina, congestive heart failure, and peripheral artery disease). Although there were no significant interactions between age and treatment, the magnitude of effect in favor of atorvastatin was higher in younger versus older patients (occurrence of first MCE, hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.66 to 0.98; and HR 0.95, 95% CI 0.80 to 1.15, respectively; occurrence of any cardiovascular (CV) event, HR 0.80, 95% CI 0.71 to 0.89; and HR 0.88, 95% CI 0.79 to 0.99, respectively). These results were likely influenced by adherence, which was lower in older patients and those receiving atorvastatin compared with those receiving simvastatin. Rates of any reported serious adverse event were higher in older patients, but did not differ between the 2 statin groups. In conclusion, except for any CV events in the older group, significant reductions in primary and secondary end points were observed only in patients less than65 years of age. The safety of atorvastatin (80 mg) and simvastatin (20 to 40 mg) was similar in patients aged less than65 and greater than65 years with stable coronary disease. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Holme, I.u Ullevål University Hospital4 aut |
700 | 1 | a Cater, N.B.u Pfizer Inc4 aut |
700 | 1 | a Szarek, M.u Pfizer Inc4 aut |
700 | 1 | a Faergeman, O.u Århus University Hospital4 aut |
700 | 1 | a Kastelein, J.J.P.u Academic Hospital Amsterdam4 aut |
700 | 1 | a Olsson, Andersu Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US4 aut0 (Swepub:liu)andol21 |
700 | 1 | a Larsen, M.L.u Århus University Hospital4 aut |
700 | 1 | a Lindahl, C.u Pfizer Sweden4 aut |
700 | 1 | a Pedersen, T.R.u Ullevål University Hospital4 aut |
710 | 2 | a Helsinki University Central Hospitalb Ullevål University Hospital4 org |
773 | 0 | t American Journal of Cardiologyd : Elsevier BVg 103:5, s. 577-582q 103:5<577-582x 0002-9149 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18830 |
856 | 4 8 | u https://doi.org/10.1016/j.amjcard.2008.10.029 |
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