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Sex Hormones and Ad...
Sex Hormones and Adrenal Steroids : Biological Variation Estimated Using Direct and Indirect Methods
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- Roys, Eirik Åsen (författare)
- Haukeland Hosp, Norway
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- Guldhaug, Nora Alicia (författare)
- Haukeland Hosp, Norway
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- Viste, Kristin (författare)
- Haukeland Hosp, Norway
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- Jones, Graham Dallas (författare)
- St Vincents Hosp, Australia; Univ New SouthWales, Australia
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- Alaour, Bashir (författare)
- Kings Coll London, England
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- Sylte, Marit Sverresdotter (författare)
- Haukeland Hosp, Norway
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- Torsvik, Janniche (författare)
- Haukeland Hosp, Norway
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- Kellmann, Ralf (författare)
- Haukeland Hosp, Norway
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- Strand, Heidi (författare)
- Akershus Univ Hosp, Norway
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- Theodorsson, Elvar (författare)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Marber, Michael (författare)
- Kings Coll London, England
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- Omland, Torbjorn (författare)
- Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Aakre, Kristin Moberg (författare)
- Haukeland Hosp, Norway; Haukeland Hosp, Norway; Univ Bergen, Norway; Haukeland Hosp, Norway
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(creator_code:org_t)
- 2022-11-14
- 2023
- Engelska.
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Ingår i: Clinical Chemistry. - : Oxford University Press. - 0009-9147 .- 1530-8561. ; 69:1, s. 100-109
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Biological variation (BV) data may be used to develop analytical performance specifications (APS), reference change values (RCV), and support the applicability of population reference intervals. This study estimates within-subject BV (CVI) for several endocrine biomarkers using 3 different methodological approaches. Methods For the direct method, 30 healthy volunteers were sampled weekly for 10 consecutive weeks. Samples were analyzed in duplicate for 17-hydroxyprogesterone (17-OHP), androstenedione, cortisol, cortisone, estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), and testosterone. A CV-ANOVA with outlier removal and a Bayesian model were applied to derive the CVI. For estradiol, FSH and LH, only the male subgroup was included. In the indirect method, using the same analytes and groups, pairs of sequential results were extracted from the laboratory information system. The total result variation for individual pairs was determined by identifying a central gaussian distribution in the ratios of the result pairs. The CVI was then estimated by removing the effect of analytical variation. Results The estimated CVI from the Bayesian model (mu CVP(i)) in the total cohort was: 17-OHP, 23%; androstenedione, 20%; cortisol, 18%; cortisone, 11%; SHBG, 7.4%; testosterone, 16%; and for the sex hormones in men: estradiol, 14%; FSH, 8%; and LH, 26%. CVI-heterogeneity was present for most endocrine markers. Similar CVI data were estimated using the CV-ANOVA and the indirect method. Conclusions Similar CVI data were obtained using 2 different direct and one indirect method. The indirect approach is a low-cost alternative ensuring implementation of CVI data applicable for local conditions.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Nyckelord
- quality control; LC-MS; adrenal; steroids and steroid hormones; testosterone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Roys, Eirik Åsen
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Guldhaug, Nora A ...
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Viste, Kristin
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Jones, Graham Da ...
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Alaour, Bashir
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Sylte, Marit Sve ...
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visa fler...
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Torsvik, Jannich ...
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Kellmann, Ralf
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Strand, Heidi
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Theodorsson, Elv ...
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Marber, Michael
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Omland, Torbjorn
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Aakre, Kristin M ...
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk labora ...
- Artiklar i publikationen
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Clinical Chemist ...
- Av lärosätet
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Linköpings universitet