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Association between...
Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort
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- Vielot, Nadja Alexandra (författare)
- Univ N Carolina, NC 27515 USA
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- Francois, Ruthly (författare)
- Univ N Carolina, NC 27515 USA
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- Huseynova, Emilya (författare)
- Univ N Carolina, NC 27515 USA
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- Gonzalez, Fredman (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Reyes, Yaoska (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Gutierrez, Lester (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Nordgren, Johan (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Toval-Ruiz, Christian (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Vilchez, Samuel (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Vinje, Jan (författare)
- Ctr Dis Control & Prevent, GA USA
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- Becker-Dreps, Sylvia (författare)
- Univ N Carolina, NC 27515 USA; Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Bucardo, Filemon (författare)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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(creator_code:org_t)
- 2022-10-14
- 2022
- Engelska.
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 17:10
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. Methods We investigated the association between breastfeeding and norovirus or sapovirus AGE episodes in a birth cohort. Weekly data on breastfeeding and AGE episodes were captured during the first year of life. Stools were collected from children with AGE and tested by RT-qPCR for norovirus and sapovirus. Time-dependent Cox models estimated associations between weekly breastfeeding and time to first norovirus or sapovirus AGE. Findings From June 2017 to July 2018, 444 newborns were enrolled in the study. In the first year of life, 69 and 34 children experienced a norovirus and a sapovirus episode, respectively. Exclusive breastfeeding lasted a median of 2 weeks, and any breastfeeding lasted a median of 43 weeks. Breastfeeding in the last week did not prevent norovirus (HR: 1.09, 95% CI: 0.62, 1.92) or sapovirus (HR: 1.00, 95% CI: 0.82, 1.21) AGE in a given week, adjusting for household sanitation, consumption of high-risk foods, and mothers and childs histo-blood group phenotypes. Maternal secretor-positive phenotype was protective against norovirus AGE, whereas childs secretor-positive phenotype was a risk factor for norovirus AGE. Interpretation Exclusive breastfeeding in this population was short-lived, and no conclusions could be drawn about its potential to prevent norovirus or sapovirus AGE. Non-exclusive breastfeeding did not prevent norovirus or sapovirus AGE in the first year of life. However, maternal secretor-positive phenotype was associated with a reduced hazard of norovirus AGE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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Vielot, Nadja Al ...
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Francois, Ruthly
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Huseynova, Emily ...
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Gonzalez, Fredma ...
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Reyes, Yaoska
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Gutierrez, Leste ...
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visa fler...
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Nordgren, Johan
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Toval-Ruiz, Chri ...
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Vilchez, Samuel
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Vinje, Jan
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Becker-Dreps, Sy ...
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Bucardo, Filemon
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