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Antibiotic treatmen...
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review
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- Vernhardsdottir, R.R. (author)
- Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway
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- Magno, M.S. (author)
- Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway; Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Ophthalmology, Sørlandet Hospital Arendal, Arendal, Norway
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- Hynnekleiv, L. (author)
- Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway; Department of Twin Research & Genetic Epidemiology, Kings College London, St Thomas Hospital, London, United Kingdom
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- Lagali, Neil S, 1973- (author)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,Department of Ophthalmology, Sørlandet Hospital Arendal, Arendal, Norway
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- Dartt, D.A. (author)
- Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford St, Boston, MA 02114, United States
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- Vehof, J. (author)
- Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway; Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Twin Research & Genetic Epidemiology, Kings College London, St Thomas Hospital, London, United Kingdom; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Dutch Dry Eye Clinic, Emmastraat 21, Velp6881SN, Netherlands
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- Jackson, C.J. (author)
- Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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- Utheim, T.P. (author)
- Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; The Norwegian Dry Eye Clinic, Oslo, Norway
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(creator_code:org_t)
- Elsevier Inc. 2022
- 2022
- English.
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In: Ocular Surface. - : Elsevier Inc.. - 1542-0124. ; 26, s. 211-221
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. Antibiotics are regularly used to treat DED caused by meibomian gland dysfunction (MGD) or blepharitis, but their use has been questioned. Objective: To critically evaluate the use of oral and topical antibiotics in DED management. Methods: A literature search was conducted on November 15th, 2021, in the PubMed database. The search terms were: (antibiotics OR azithromycin OR doxycycline OR minocycline) AND (dry eye disease OR meibomian gland OR blepharitis anterior OR blepharitis posterior OR chronic blepharitis). All relevant original articles with English full-text were included. Case reports and review articles were excluded. Results: The search provided 619 articles, of which 22 met the inclusion criteria. Oral and topical antibiotics appeared to have short-term positive effects on signs and symptoms of blepharitis- or MGD-related DED. However, these improvements often reverted upon cessation of treatment. The need for repeated treatments and mild adverse events were common. Conclusions: Current evidence suggests that patients with blepharitis- or MGD-related DED experience short-term benefits of antibiotics. However, evidence for lasting improvement after completed treatment was lacking. Given the unclear long-term benefits, common side effects, and increasing antibiotic resistance seen globally, the existing literature is not sufficient to conclude that antibiotics are useful in long-term MGD management. A survival-analysis of a single round of antibiotics, in addition to the effects of repeated rounds of treatment, on DED parameters could provide useful insights. © 2022 Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
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