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The Notch-mediated ...
The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model
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- Mitsiadis, Thimios A. (författare)
- Univ Zurich, Switzerland
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- Pagella, Pierfrancesco (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Univ Zurich, Switzerland,Wallenberg Center for Molecular Medicine (WCMM)
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- Capellini, Terence D. (författare)
- Harvard Univ, MA 02138 USA
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- Smith, Moya Meredith (författare)
- Kings Coll London, England
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(creator_code:org_t)
- SPRINGER BASEL AG, 2023
- 2023
- Engelska.
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : SPRINGER BASEL AG. - 1420-682X .- 1420-9071. ; 80:7
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Notch pathway is an ancient, evolutionary conserved intercellular signaling mechanism that is involved in cell fate specification and proper embryonic development. The Jagged2 gene, which encodes a ligand for the Notch family of receptors, is expressed from the earliest stages of odontogenesis in epithelial cells that will later generate the enamel-producing ameloblasts. Homozygous Jagged2 mutant mice exhibit abnormal tooth morphology and impaired enamel deposition. Enamel composition and structure in mammals are tightly linked to the enamel organ that represents an evolutionary unit formed by distinct dental epithelial cell types. The physical cooperativity between Notch ligands and receptors suggests that Jagged2 deletion could alter the expression profile of Notch receptors, thus modifying the whole Notch signaling cascade in cells within the enamel organ. Indeed, both Notch1 and Notch2 expression are severely disturbed in the enamel organ of Jagged2 mutant teeth. It appears that the deregulation of the Notch signaling cascade reverts the evolutionary path generating dental structures more reminiscent of the enameloid of fishes rather than of mammalian enamel. Loss of interactions between Notch and Jagged proteins may initiate the suppression of complementary dental epithelial cell fates acquired during evolution. We propose that the increased number of Notch homologues in metazoa enabled incipient sister cell types to form and maintain distinctive cell fates within organs and tissues along evolution.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Notch signaling; Tooth development; Enamel; Cell commitment; Enamel organ; Ameloblasts; Evolution; Jagged
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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