Sökning: onr:"swepub:oai:DiVA.org:liu-197884" > Elevated atrial blo...
Fältnamn | Indikatorer | Metadata |
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000 | 05420naa a2200409 4500 | |
001 | oai:DiVA.org:liu-197884 | |
003 | SwePub | |
008 | 230919s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1978842 URI |
024 | 7 | a https://doi.org/10.3389/fcvm.2023.12190212 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bäck, Sophiau Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)sopbe21 |
245 | 1 0 | a Elevated atrial blood stasis in paroxysmal atrial fibrillation during sinus rhythm: a patient-specific computational fluid dynamics study |
264 | 1 | b FRONTIERS MEDIA SA,c 2023 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|This project was funded by the Swedish Medical Research Council (2018-02779); the Swedish research council (2018-04454), ALF Grants, Region Ouml;stergouml;tland (974839 and 969563); Swedish Heart and Lung Foundation (20200220 and 20210441), VINNOVA (2019 [2018-04454]; Swedish Medical Research Council [974839]; Swedish research council [969563, 20200220]; ALF Grants [20210441, 2019-02261]; Swedish Heart and Lung Foundation [2021/3-35]; VINNOVA; Henry och Ella Sthls foundation; Swedish National Infrastructure for Computing (SNIC) - Swedish Research Council; [2018-02779] | |
520 | a Introduction: Atrial fibrillation (AF) is associated with an increased risk of stroke, often caused by thrombi that form in the left atrium (LA), and especially in the left atrial appendage (LAA). The underlying mechanism is not fully understood but is thought to be related to stagnant blood flow, which might be present despite sinus rhythm. However, measuring blood flow and stasis in the LAA is challenging due to its small size and low velocities. We aimed to compare the blood flow and stasis in the left atrium of paroxysmal AF patients with controls using computational fluid dynamics (CFD) simulations.Methods : The CFD simulations were based on time-resolved computed tomography including the patient-specific cardiac motion. The pipeline allowed for analysis of 21 patients with paroxysmal AF and 8 controls. Stasis was estimated by computing the blood residence time.Results and Discussion: Residence time was elevated in the AF group (p < 0.001). Linear regression analysis revealed that stasis was strongest associated with LA ejection ratio (p < 0.001, R-2 = 0.68) and the ratio of LA volume and left ventricular stroke volume (p < 0.001, R-2 = 0.81). Stroke risk due to LA thrombi could already be elevated in AF patients during sinus rhythm. In the future, patient specific CFD simulations may add to the assessment of this risk and support diagnosis and treatment. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a atrial fibrillation; computational fluid dynamics; left atrial appendage; computed tomography; atrial cardiomyopathy; stroke | |
700 | 1 | a Skoda, Iuliau Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)iulsk88 |
700 | 1 | a Lantz, Jonasu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)jonla63 |
700 | 1 | a Henriksson, Lilianu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping4 aut0 (Swepub:liu)lilhe58 |
700 | 1 | a Karlsson, Larsu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)larka64 |
700 | 1 | a Persson, Andersu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping4 aut0 (Swepub:liu)andpe75 |
700 | 1 | a Carlhäll, Carljohanu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US4 aut0 (Swepub:liu)carca13 |
700 | 1 | a Ebbers, Tinou Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)tineb49 |
710 | 2 | a Linköpings universitetb Avdelningen för diagnostik och specialistmedicin4 org |
773 | 0 | t Frontiers in Cardiovascular Medicined : FRONTIERS MEDIA SAg 10q 10x 2297-055X |
856 | 4 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201507y Correction |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1798433/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197884 |
856 | 4 8 | u https://doi.org/10.3389/fcvm.2023.1219021 |
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