Sökning: onr:"swepub:oai:DiVA.org:liu-199441" >
Molecular Mechanism...
Molecular Mechanisms of Glaucoma Pathogenesis with Implications to Caveolin Adaptor Protein and Caveolin-Shp2 Axis
-
- Abbasi, Mojdeh (författare)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Macquarie Univ, Australia
-
- Gupta, Vivek (författare)
- Macquarie Univ, Australia
-
- Chitranshi, Nitin (författare)
- Macquarie Univ, Australia
-
visa fler...
-
- Moustardas, Petros (författare)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten
-
- Ranjbaran, Reza (författare)
- Shiraz Univ Med Sci, Iran
-
- Graham, Stuart L. (författare)
- Macquarie Univ, Australia
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Aging and Disease. - : INT SOC AGING & DISEASE. - 2152-5250.
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Glaucoma is a common retinal disorder characterized by progressive optic nerve damage, resulting in visual impairment and potential blindness. Elevated intraocular pressure (IOP) is a major risk factor, but some patients still experience disease progression despite IOP-lowering treatments. Genome-wide association studies have linked variations in the Caveolin1/2 (CAV-1/2) gene loci to glaucoma risk. Cav-1, a key protein in caveolae membrane invaginations, is involved in signaling pathways and its absence impairs retinal function. Recent research suggests that Cav-1 is implicated in modulating the BDNF/TrkB signaling pathway in retinal ganglion cells, which plays a critical role in retinal ganglion cell (RGC) health and protection against apoptosis. Understanding the interplay between these proteins could shed light on glaucoma pathogenesis and provide potential therapeutic targets.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- retina; glaucoma; Caveolin; Shp2 phosphatase; IOP; RGCs
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas