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Childbirth rates in...
Childbirth rates in women with myeloproliferative neoplasms
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- Landtblom, Anna Ravn (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Andersson, Therese M-L (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Johansson, Anna L. V. (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Canc Registry Norway, Norway
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- Lundberg, Frida E. (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Samuelsson, Jan (author)
- Region Östergötland, Hematologiska kliniken US
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- Bjorkholm, Magnus (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Hultcrantz, Malin (author)
- Karolinska Inst, Sweden; Mem Sloan Kettering Canc Ctr, NY USA
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Leukemia. - : SPRINGERNATURE. - 0887-6924 .- 1476-5551.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Myeloproliferative neoplasms (MPN) are associated with inferior pregnancy outcome, however, little is known about fertility and childbearing potential in women with MPN. In this study we aimed to describe reproductive patterns, as well as to quantify risk of miscarriage and stillbirth. Women aged 15-44 years with an MPN diagnosis 1973-2018, were identified in Swedish health care registers, and age-matched 1:4 to population controls. We identified 1141 women with MPN and 4564 controls. Women with MPN had a lower rate of childbirth (hazard ratio [HR] with 95% confidence interval was 0.78 (0.68-0.90)). Subgroup analysis showed that the rate was not significantly reduced in essential thrombocythemia, HR 1.02 (0.86-1.22) while the HR was 0.50 (0.33-0.76) in PV and 0.45 (0.28-0.74) in PMF. The risk of miscarriage was not significantly increased before MPN diagnosis, the HR during follow-up after diagnosis was 1.25 (0.89-1.76). Women with MPN were more likely to have had a previous stillbirth. Women with MPN had fewer children at diagnosis, and fewer children in total. In conclusion, the childbirth rate was lower among women with MPN than controls, but not among women with essential thrombocythemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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