Search: onr:"swepub:oai:DiVA.org:liu-204341" >
A targetable fluore...
A targetable fluorescent probe for detecting mitochondrial viscosity in live cells by using fluorescence lifetime imaging
-
- Gong, Zheng (author)
- Anhui Univ, Peoples R China
-
- Wang, Xue (author)
- Chuzhou Univ, Peoples R China
-
- Ma, Haowen (author)
- Chuzhou Univ, Peoples R China
-
show more...
-
- Wei, Bing (author)
- Anhui Univ, Peoples R China
-
- Wang, Xiaojuan (author)
- Anhui Univ, Peoples R China; Chuzhou Univ, Peoples R China
-
- Zhu, Yingzhong (author)
- Anhui Univ, Peoples R China; Chuzhou Univ, Peoples R China
-
- Hu, Zhang-Jun (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
-
- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
-
- Liu, Zhengjie (author)
- Anhui Univ, Peoples R China
-
- Zhang, Zhongping (author)
- Anhui Univ, Peoples R China
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: New Journal of Chemistry. - : ROYAL SOC CHEMISTRY. - 1144-0546 .- 1369-9261.
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Intracellular viscosity plays an important role in regulating cellular morphology and physiology and is closely related to a host of diseases. Especially, the changes in mitochondrial viscosity will cause some common diseases such as hyperlipidemia, Alzheimer's disease and cancer. In this work, we report the design of a red-emissive molecular rotor for the detection of mitochondrial viscosity in live cells. The probe showed fascinating performance, such as specific targeting to mitochondria, high sensitivity to viscosity, and rapid fluorescence response, especially the dual response mode of fluorescence intensity and fluorescence lifetime. By using this probe, we realized monitoring of the mitochondrial viscosity variations in live cells under different physiological processes. Our study offers an opportunity to discover potential tools for mitochondria-related physiology and pathology investigation. A D-pi-A typed fluorescence lifetime probe for sensitively detecting viscosity has been designed and synthesized. BSOH has been successfully applied to real-time monitoring mitochondrial viscosity in live cells by fluorescence lifetime imaging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gong, Zheng
-
Wang, Xue
-
Ma, Haowen
-
Wei, Bing
-
Wang, Xiaojuan
-
Zhu, Yingzhong
-
show more...
-
Hu, Zhang-Jun
-
Uvdal, Kajsa
-
Liu, Zhengjie
-
Zhang, Zhongping
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Other Basic Medi ...
- Articles in the publication
-
New Journal of C ...
- By the university
-
Linköping University