Search: onr:"swepub:oai:DiVA.org:liu-21140" >
Complications Carot...
Complications Carotid intima-media thickness and apolipoprotein B/apolipoprotein A-I ratio in middle-aged patients with Type 2 diabetes
-
- Dahlén, Elsa M (author)
- Östergötlands Läns Landsting,Linköpings universitet,Allmänmedicin,Hälsouniversitetet,Avdelningen för samhällsmedicin,Närsjukvården i västra Östergötland
-
- Länne, Toste (author)
- Östergötlands Läns Landsting,Linköpings universitet,Fysiologi,Kärlkirurgi,Thorax-kärlkliniken,Hälsouniversitetet
-
- Engvall, Jan (author)
- Linköpings universitet,Östergötlands Läns Landsting,Fysiologiska kliniken,Klinisk fysiologi,Hälsouniversitetet,Avdelningen för kardiovaskulär medicin
-
show more...
-
- Lindström, T (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US,Hälsouniversitetet,Avdelningen för kardiovaskulär medicin
-
- Grodzinsky, Ewa (author)
- Linköpings universitet,Östergötlands Läns Landsting,Närsjukvården i centrala Östergötland,Allmänmedicin,Hälsouniversitetet,Hälsa, Aktivitet, Vård (HAV),Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland
-
- Nyström, Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US,Hälsouniversitetet,Avdelningen för kardiovaskulär medicin
-
- Östgren, Carl Johan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Allmänmedicin,Hälsouniversitetet,Primärvården i västra länsdelen,Avdelningen för samhällsmedicin,Närsjukvården i västra Östergötland
-
show less...
-
(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
-
In: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 26:4, s. 384-390
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- AIMS: To explore the association between carotid intima-media thickness (IMT) and the apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio compared with conventional lipids in middle-aged patients with Type 2 diabetes. METHODS: We analysed data from 247 patients with Type 2 diabetes, aged 55-66 years, in the Cardiovascular Risk factors in Patients with Diabetes-a Prospective study in Primary care (CARDIPP-1) study. Primary care nurses measured blood pressure and anthropometric characteristics. Blood samples were taken for laboratory analyses. The carotid IMT was determined by ultrasonography at the University Hospital in Linköping and at the County Hospital Ryhov, Jönköping, Sweden. RESULTS: The ApoB/apoA-I ratio (r = 0.207, P = 0.001), apoB (r = 0.166, P = 0.009) and non-high-density lipoprotein cholesterol (non-HDL-c) (r = 0.129, P = 0.046) correlated with IMT. Conventional lipids, high-sensitivity C-reactive protein (hsCRP), glycated haemoglobin (HbA(1c)) and systolic blood pressure were not significantly correlated to IMT. A stepwise logistic regression analysis was conducted with IMT as the dependent variable and the apoB/apoA-I ratio, HbA(1c), hsCRP, low-density lipoprotein cholesterol (LDL-c), total cholesterol, non-HDL-c and treatment with statins as independent variables. Following adjustment for age and gender, only the apoB/apoA-I ratio remained significantly associated with IMT (odds ratio 4.3, 95% confidence intervals 1.7-10.8, P = 0.002). CONCLUSIONS: We conclude that there was a significant association between the apoB/apoA-I ratio and IMT in middle-aged patients with Type 2 diabetes. The association was independent of conventional lipids, hsCRP, glycaemic control and use of statins.
Keyword
- apolipoproteins
- cardiovascular disease
- lipid metabolism
- type 2 diabetes
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database