Myocardial uptake and release of substrates in patients operated for unstable angina: Impact of glutamate infusion

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Fältnamn	Indikatorer	Metadata
000		03232naa a2200361 4500
001		oai:DiVA.org:liu-26947
003		SwePub
008		091008s2003 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:1947102
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-269472 URI
024	7	a https://doi.org/10.1080/140174303100012302 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:19471022 URI
040		a (SwePub)liud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Vanhanen, Ingemaru Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Thoraxkirurgi,Thorax-kärlkliniken4 aut
245	1 0	a Myocardial uptake and release of substrates in patients operated for unstable angina :b Impact of glutamate infusion
264		c 2016-03-09
264	1	b Informa UK Limited,c 2003
338		a print2 rdacarrier
520		a Objective - To study cardiac uptake and release of substrates and the influence of intravenous glutamate in patients operated for unstable angina requiring intravenous nitrates. Design - Nineteen patients were randomized to blinded infusion of glutamate or saline. Arterial-coronary sinus differences of substrates were measured before cardiopulmonary bypass (CPB) and during early reperfusion. Results - Before CPB the only major substrates that were extracted by the heart in the saline group were free fatty acids (FFAs). During reperfusion uptake of glucose and glutamate was found but FFAs remained the major substrate extracted by the heart. Initially transient low oxygen extraction and lactate release were found. Conversion to lactate uptake was not observed. Glutamate infusion was associated with an uptake of glutamate and in contrast to the control group there was also uptake of lactate before CPB and at the end of the study period. Conclusion - The metabolic situation before CPB with a reliance on myocardial FFA uptake is less than ideal with regard to ischemia. Early reperfusion was characterized by dynamic changes and a shift towards myocardial glucose uptake but FFAs remained the major substrate extracted. The qualitative findings associated with glutamate infusion agree with previous animal and human studies but have to be interpreted cautiously due to lack of flow measurements.
653		a MEDICINE
653		a MEDICIN
700	1	a Håkansson, Eriku Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Anestesiologi,Thorax-kärlkliniken4 aut
700	1	a Jorfeldt, Lennartu Karolinska Institutet4 aut
700	1	a Svedjeholm, Rolf,d 1952-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Thoraxkirurgi,Thorax-kärlkliniken4 aut0 (Swepub:liu)rolsv84
710	2	a Linköpings universitetb Hälsouniversitetet4 org
773	0	t Scandinavian Cardiovascular Journald : Informa UK Limitedg 37:2, s. 113-120q 37:2<113-120x 1401-7431x 1651-2006
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26947
856	4 8	u https://doi.org/10.1080/14017430310001230
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:1947102

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